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Target
Sodium/hydrogen exchanger 1
Ligand
BDBM50191839
Substrate
n/a
Meas. Tech.
ChEMBL_397780 (CHEMBL856311)
IC50
5.4±n/a nM
Citation
Atwal, KS; O'Neil, SV; Ahmad, S; Doweyko, L; Kirby, M; Dorso, CR; Chandrasena, G; Chen, BC; Zhao, R; Zahler, R Synthesis and biological activity of 5-aryl-4-(4-(5-methyl-1H-imidazol-4-yl)piperidin-1-yl)pyrimidine analogs as potent, highly selective, and orally bioavailable NHE-1 inhibitors. Bioorg Med Chem Lett 16:4796-9 (2006) [PubMed] Article
More Info.:
Target
Name:
Sodium/hydrogen exchanger 1
Synonyms:
APNH | APNH1 | NHE-1 | NHE1 | Na(+)/H(+) antiporter, amiloride-sensitive | Na(+)/H(+) exchanger 1 | SL9A1_HUMAN | SLC9A1 | Solute carrier family 9 member 1
Type:
PROTEIN
Mol. Mass.:
90771.96
Organism:
Homo sapiens (Human)
Description:
ChEMBL_862405
Residue:
815
Sequence:
MVLRSGICGLSPHRIFPSLLVVVALVGLLPVLRSHGLQLSPTASTIRSSEPPRERSIGDVTTAPPEVTPESRPVNHSVTDHGMKPRKAFPVLGIDYTHVRTPFEISLWILLACLMKIGFHVIPTISSIVPESCLLIVVGLLVGGLIKGVGETPPFLQSDVFFLFLLPPIILDAGYFLPLRQFTENLGTILIFAVVGTLWNAFFLGGLMYAVCLVGGEQINNIGLLDNLLFGSIISAVDPVAVLAVFEEIHINELLHILVFGESLLNDAVTVVLYHLFEEFANYEHVGIVDIFLGFLSFFVVALGGVLVGVVYGVIAAFTSRFTSHIRVIEPLFVFLYSYMAYLSAELFHLSGIMALIASGVVMRPYVEANISHKSHTTIKYFLKMWSSVSETLIFIFLGVSTVAGSHHWNWTFVISTLLFCLIARVLGVLGLTWFINKFRIVKLTPKDQFIIAYGGLRGAIAFSLGYLLDKKHFPMCDLFLTAIITVIFFTVFVQGMTIRPLVDLLAVKKKQETKRSINEEIHTQFLDHLLTGIEDICGHYGHHHWKDKLNRFNKKYVKKCLIAGERSKEPQLIAFYHKMEMKQAIELVESGGMGKIPSAVSTVSMQNIHPKSLPSERILPALSKDKEEEIRKILRNNLQKTRQRLRSYNRHTLVADPYEEAWNQMLLRRQKARQLEQKINNYLTVPAHKLDSPTMSRARIGSDPLAYEPKEDLPVITIDPASPQSPESVDLVNEELKGKVLGLSRDPAKVAEEDEDDDGGIMMRSKETSSPGTDDVFTPAPSDSPSSQRIQRCLSDPGPHPEPGEGEPFFPKGQ