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Target
5-hydroxytryptamine receptor 6
Ligand
BDBM50194452
Substrate
n/a
Meas. Tech.
ChEMBL_424391 (CHEMBL911322)
Ki
143±n/a nM
Citation
 Kolanos, R; Dukat, M; Roth, BL; Glennon, RA Interaction of N1-unsubstituted and N1-benzenesulfonyltryptamines at h5-HT6 receptors. Bioorg Med Chem Lett 16:5832-5 (2006) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 6
Synonyms:
5-HT-6 | 5-HT6 | 5-hydroxytryptamine receptor 6 (5-HT-6) | 5-hydroxytryptamine receptor 6 (5-HT6R) | 5-hydroxytryptamine receptor 6 (5HT6) | 5HT6R_HUMAN | HTR6 | Serotonin (5-HT3) receptor | Serotonin 6 (5-HT6) receptor | Serotonin Receptor 6
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46968.43
Organism:
Homo sapiens (Human)
Description:
P50406
Residue:
440
Sequence:
MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQCRLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVPRTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGPRPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNFFNIDPAEPELRPHPLGIPTN
  
Inhibitor
Name:
BDBM50194452
Synonyms:
CHEMBL375594 | [2-(5,5-dioxo-5H-5lambda6-thia-4b-aza-indeno[2,1-a]inden-10-yl)-ethyl]-dimethyl-amine
Type:
Small organic molecule
Emp. Form.:
C18H18N2O2S
Mol. Mass.:
326.413
SMILES:
CN(C)CCc1c2-c3ccccc3S(=O)(=O)n2c2ccccc12
Structure:
Search PDB for entries with ligand similarity: