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Target
Alpha-2B adrenergic receptor
Ligand
BDBM50196111
Substrate
n/a
Meas. Tech.
ChEMBL_406589 (CHEMBL907693)
Ki
2500±n/a nM
Citation
 Höglund, IP; Silver, S; Engström, MT; Salo, H; Tauber, A; Kyyrönen, HK; Saarenketo, P; Hoffrén, AM; Kokko, K; Pohjanoksa, K; Sallinen, J; Savola, JM; Wurster, S; Kallatsa, OA Structure-activity relationship of quinoline derivatives as potent and selective alpha(2C)-adrenoceptor antagonists. J Med Chem 49:6351-63 (2006) [PubMed]  Article 
Target
Name:
Alpha-2B adrenergic receptor
Synonyms:
ADA2B_HUMAN | ADRA2B | ADRA2L1 | ADRA2RL1 | Adrenergic alpha2B | Adrenergic receptor | Adrenergic receptor alpha | Adrenergic, alpha-2B-, receptor [Homo sapiens] | Alpha-2 adrenergic receptor subtype C2 | Alpha-2B adrenoceptor | Alpha-2B adrenoreceptor | Alpha-2BAR
Type:
Enzyme
Mol. Mass.:
49964.20
Organism:
Homo sapiens (Human)
Description:
P18089
Residue:
450
Sequence:
MDHQDPYSVQATAAIAAAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELLGYWYFRRTWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEYNSKRTPRRIKCIILTVWLIAAVISLPPLIYKGDQGPQPRGRPQCKLNQEAWYILASSIGSFFAPCLIMILVYLRIYLIAKRSNRRGPRAKGGPGQGESKQPRPDHGGALASAKLPALASVASAREVNGHSKSTGEKEEGETPEDTGTRALPPSWAALPNSGQGQKEGVCGASPEDEAEEEEEEEEEEEECEPQAVPVSPASACSPPLQQPQGSRVLATLRGQVLLGRGVGAIGGQWWRRRAQLTREKRFTFVLAVVIGVFVLCWFPFFFSYSLGAICPKHCKVPHGLFQFFFWIGYCNSSLNPVIYTIFNQDFRRAFRRILCRPWTQTAW
  
Inhibitor
Name:
BDBM50196111
Synonyms:
4-(3-methyltetrahydropyrimidin-1(2H)-yl)phenyl]-(2,3,8-trimethylquinolin-4-yl)amine | CHEMBL216072
Type:
Small organic molecule
Emp. Form.:
C23H28N4
Mol. Mass.:
360.4952
SMILES:
CN1CCCN(C1)c1ccc(Nc2c(C)c(C)nc3c(C)cccc23)cc1
Structure:
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