Reaction Details Report a problem with these data
Target
Neuropeptide Y receptor type 2
Ligand
BDBM50197011
Substrate
n/a
Meas. Tech.
ChEMBL_453180 (CHEMBL902330)
EC50
11±n/a nM
Citation
 DeCarr, LB; Buckholz, TM; Coish, PD; Fathi, Z; Fisk, SE; Mays, MR; O'Connor, SJ; Lumb, KJ Identification of selective neuropeptide Y2 peptide agonists. Bioorg Med Chem Lett 17:538-41 (2007) [PubMed]  Article 
Target
Name:
Neuropeptide Y receptor type 2
Synonyms:
NPY-Y2 | NPY-Y2 receptor | NPY2-R | NPY2R | NPY2R_HUMAN | Neuropeptide Y receptor type 2 | Y2 receptor | neuropeptide Y receptor Y2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42734.65
Organism:
Homo sapiens (Human)
Description:
NPY-Y2 NPY2R HUMAN::P49146
Residue:
381
Sequence:
MGPIGAEADENQTVEEMKVEQYGPQTTPRGELVPDPEPELIDSTKLIEVQVVLILAYCSIILLGVIGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAVQVSTITLTVIALDRHRCIVYHLESKISKRISFLIIGLAWGISALLASPLAIFREYSLIEIIPDFEIVACTEKWPGEEKSIYGTVYSLSSLLILYVLPLGIISFSYTRIWSKLKNHVSPGAANDHYHQRRQKTTKMLVCVVVVFAVSWLPLHAFQLAVDIDSQVLDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAFLSAFRCEQRLDAIHSEVSVTFKAKKNLEVRKNSGPNDSFTEATNV
  
Inhibitor
Name:
BDBM50197011
Synonyms:
CHEMBL238533 | PYY(22-36)
Type:
Small organic molecule
Emp. Form.:
C84H137N29O21
Mol. Mass.:
1889.1683
SMILES:
CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](C)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O |wU:84.85,14.15,69.70,31.30,85.88,102.103,53.54,4.4,122.123,wD:20.19,77.78,41.41,91.92,8.10,61.62,111.112,(-4.56,-28.45,;-4.56,-29.99,;-3.22,-30.76,;-5.89,-30.76,;-5.89,-32.3,;-7.22,-33.07,;-8.56,-32.3,;-8.56,-30.76,;-9.89,-33.07,;-9.89,-34.61,;-8.57,-35.38,;-11.22,-32.3,;-12.55,-33.08,;-12.55,-34.62,;-13.88,-32.31,;-13.88,-30.77,;-15.22,-33.08,;-4.56,-33.07,;-4.56,-34.61,;-3.23,-32.29,;-1.9,-33.05,;-1.9,-34.59,;-.57,-35.36,;-.57,-36.9,;.76,-37.67,;.78,-39.21,;-.56,-39.98,;2.11,-39.98,;-.57,-32.28,;-.57,-30.74,;.76,-33.05,;2.11,-32.3,;2.11,-30.76,;3.43,-29.99,;4.84,-30.62,;5.87,-29.47,;5.1,-28.14,;3.6,-28.45,;3.43,-33.07,;3.43,-34.61,;4.77,-32.29,;6.1,-33.06,;6.1,-34.6,;7.43,-35.37,;8.77,-34.6,;10.1,-35.37,;10.1,-36.91,;11.42,-37.68,;8.77,-37.68,;7.43,-36.91,;7.43,-32.29,;7.43,-30.75,;8.76,-33.06,;10.1,-32.29,;10.1,-30.75,;11.43,-29.98,;11.43,-28.44,;12.76,-30.75,;11.43,-33.06,;11.43,-34.6,;12.76,-32.29,;14.09,-33.06,;14.09,-34.6,;15.42,-35.37,;16.76,-34.6,;15.42,-36.91,;15.42,-32.29,;15.42,-30.75,;16.76,-33.06,;18.1,-32.29,;18.1,-30.75,;19.43,-29.98,;19.43,-28.44,;20.76,-30.75,;19.43,-33.06,;19.43,-34.6,;20.76,-32.29,;22.09,-33.06,;22.09,-34.6,;23.42,-35.37,;20.75,-35.37,;23.42,-32.29,;23.42,-30.75,;24.75,-33.06,;26.09,-32.29,;26.09,-30.75,;24.75,-29.98,;27.41,-29.97,;27.42,-33.06,;27.42,-34.6,;28.75,-32.29,;30.08,-33.06,;30.08,-34.6,;31.41,-35.37,;31.41,-36.91,;32.75,-37.68,;32.75,-39.22,;31.42,-39.99,;34.09,-39.99,;31.41,-32.29,;31.41,-30.75,;32.75,-33.06,;34.08,-32.29,;34.08,-30.75,;35.41,-29.98,;35.41,-28.44,;34.08,-27.67,;36.75,-27.67,;35.41,-33.06,;35.41,-34.6,;36.74,-32.29,;38.08,-33.06,;38.08,-34.6,;39.41,-35.37,;39.41,-36.91,;40.74,-37.67,;40.74,-39.21,;39.4,-39.98,;42.08,-39.98,;39.41,-32.29,;39.41,-30.75,;40.74,-33.06,;42.07,-32.29,;42.07,-30.75,;43.4,-29.98,;44.74,-30.75,;46.08,-29.98,;46.08,-28.44,;47.4,-27.67,;44.74,-27.67,;43.4,-28.44,;43.4,-33.06,;44.74,-32.29,;43.4,-34.6,)|
Structure:
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