Reaction Details Report a problem with these data
Target
Neuropeptide Y receptor type 2
Ligand
BDBM50197014
Substrate
n/a
Meas. Tech.
ChEMBL_453177 (CHEMBL902327)
Ki
75±n/a nM
Citation
 DeCarr, LB; Buckholz, TM; Coish, PD; Fathi, Z; Fisk, SE; Mays, MR; O'Connor, SJ; Lumb, KJ Identification of selective neuropeptide Y2 peptide agonists. Bioorg Med Chem Lett 17:538-41 (2007) [PubMed]  Article 
Target
Name:
Neuropeptide Y receptor type 2
Synonyms:
NPY-Y2 | NPY-Y2 receptor | NPY2-R | NPY2R | NPY2R_HUMAN | Neuropeptide Y receptor type 2 | Y2 receptor | neuropeptide Y receptor Y2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42734.65
Organism:
Homo sapiens (Human)
Description:
NPY-Y2 NPY2R HUMAN::P49146
Residue:
381
Sequence:
MGPIGAEADENQTVEEMKVEQYGPQTTPRGELVPDPEPELIDSTKLIEVQVVLILAYCSIILLGVIGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAVQVSTITLTVIALDRHRCIVYHLESKISKRISFLIIGLAWGISALLASPLAIFREYSLIEIIPDFEIVACTEKWPGEEKSIYGTVYSLSSLLILYVLPLGIISFSYTRIWSKLKNHVSPGAANDHYHQRRQKTTKMLVCVVVVFAVSWLPLHAFQLAVDIDSQVLDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAFLSAFRCEQRLDAIHSEVSVTFKAKKNLEVRKNSGPNDSFTEATNV
  
Inhibitor
Name:
BDBM50197014
Synonyms:
AcNPY(25-36) | CHEMBL411793
Type:
Small organic molecule
Emp. Form.:
C76H119N27O18
Mol. Mass.:
1698.9282
SMILES:
CC[C@@H](C)[C@@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCNC(=O)CC[C@H](NC1=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCN=C(N)N)NC(C)=O |wU:16.16,8.8,4.3,99.109,52.52,72.72,wD:24.85,2.2,109.120,34.38,41.41,87.98,61.61,(21.95,-18.8,;20.64,-19.6,;19.29,-18.85,;19.25,-17.31,;17.96,-19.65,;16.61,-18.91,;15.29,-19.71,;15.33,-21.25,;13.94,-18.96,;13.92,-17.42,;15.24,-16.63,;15.23,-15.09,;16.58,-17.37,;12.61,-19.74,;11.26,-18.99,;11.25,-17.45,;9.93,-19.76,;8.6,-18.98,;8.6,-17.44,;9.97,-16.7,;7.27,-16.66,;9.92,-21.3,;8.59,-22.08,;7.25,-21.32,;8.6,-23.61,;9.92,-24.3,;9.94,-25.87,;11.29,-26.64,;12.65,-25.84,;14,-26.57,;15.36,-25.84,;15.36,-24.29,;16.7,-26.61,;17.68,-24.49,;19.38,-23.48,;19.34,-21.94,;18,-21.19,;16.68,-21.99,;20.71,-24.24,;20.72,-25.77,;22.06,-23.49,;23.4,-24.25,;23.41,-25.77,;24.75,-26.53,;24.76,-28.04,;26.09,-28.81,;26.09,-30.35,;24.83,-31.11,;27.46,-31.11,;24.74,-23.47,;24.73,-21.92,;26.08,-24.23,;27.4,-23.44,;27.4,-21.89,;26.05,-21.11,;26.04,-19.61,;27.32,-18.8,;24.7,-18.84,;28.72,-24.19,;28.72,-25.71,;30.05,-23.43,;31.39,-24.2,;31.39,-25.71,;32.74,-26.49,;32.75,-28,;34.09,-28.77,;34.12,-30.31,;32.8,-31.05,;35.45,-31.06,;32.73,-23.42,;32.72,-21.87,;34.07,-24.18,;35.4,-23.42,;35.4,-21.87,;36.7,-21.11,;36.7,-19.55,;38,-18.79,;39.31,-19.54,;40.6,-18.66,;39.32,-21.05,;38.02,-21.86,;36.72,-24.17,;38.05,-23.39,;36.72,-25.67,;7.29,-24.41,;7.34,-25.96,;8.68,-26.7,;6.02,-26.76,;6.06,-28.31,;7.41,-29.04,;7.44,-30.58,;8.8,-31.31,;10.11,-30.51,;11.49,-31.27,;10.07,-28.96,;8.71,-28.23,;4.66,-26.04,;3.33,-26.81,;3.36,-28.35,;1.97,-26.08,;1.94,-24.53,;3.25,-23.73,;3.37,-22.19,;4.87,-21.83,;5.67,-23.15,;4.67,-24.32,;.68,-26.91,;-.67,-26.16,;-.71,-24.62,;-1.99,-26.96,;-1.94,-28.5,;-3.26,-29.31,;-3.22,-30.85,;-4.52,-31.68,;-4.51,-33.22,;-5.82,-34.03,;-3.17,-33.95,;-3.34,-26.23,;-4.66,-27.03,;-6.02,-26.3,;-4.62,-28.58,)|
Structure:
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