Reaction Details Report a problem with these data
Target
C-C chemokine receptor type 5
Ligand
BDBM50197758
Substrate
n/a
Meas. Tech.
ChEMBL_453280 (CHEMBL902435)
IC50
>30000±n/a nM
Citation
 Wei, RG; Arnaiz, DO; Chou, YL; Davey, D; Dunning, L; Lee, W; Lu, SF; Onuffer, J; Ye, B; Phillips, G CCR5 receptor antagonists: discovery and SAR study of guanylhydrazone derivatives. Bioorg Med Chem Lett 17:231-4 (2006) [PubMed]  Article 
Target
Name:
C-C chemokine receptor type 5
Synonyms:
C-C CKR-5 | C-C chemokine receptor type 5 | CC-CKR-5 | CCR-5 | CCR5 | CCR5/mu opioid receptor complex | CCR5_HUMAN | CD_antigen=CD195 | CHEMR13 | CMKBR5 | HIV-1 fusion coreceptor
Type:
Enzyme
Mol. Mass.:
40540.21
Organism:
Homo sapiens (Human)
Description:
P51681
Residue:
352
Sequence:
MDYQVSSPIYDINYYTSEPCQKINVKQIAARLLPPLYSLVFIFGFVGNMLVILILINCKRLKSMTDIYLLNLAISDLFFLLTVPFWAHYAAAQWDFGNTMCQLLTGLYFIGFFSGIFFIILLTIDRYLAVVHAVFALKARTVTFGVVTSVITWVVAVFASLPGIIFTRSQKEGLHYTCSSHFPYSQYQFWKNFQTLKIVILGLVLPLLVMVICYSGILKTLLRCRNEKKRHRAVRLIFTIMIVYFLFWAPYNIVLLLNTFQEFFGLNNCSSSNRLDQAMQVTETLGMTHCCINPIIYAFVGEKFRNYLLVFFQKHIAKRFCKCCSIFQQEAPERASSVYTRSTGEQEISVGL
  
Inhibitor
Name:
BDBM50197758
Synonyms:
(2E)-2-[2-[(4-chlorobenzyl)oxy]-5-(diethylamino)benzylidene]hydrazinecarboximidamide | CHEMBL241468
Type:
Small organic molecule
Emp. Form.:
C19H24ClN5O
Mol. Mass.:
373.88
SMILES:
[#6]-[#6]-[#7](-[#6]-[#6])-c1ccc(-[#8]-[#6]-c2ccc(Cl)cc2)c(-[#6]=[#7]\[#7]=[#6](\[#7])-[#7])c1 |w:19.19|
Structure:
Search PDB for entries with ligand similarity: