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Target
Potassium voltage-gated channel subfamily A member 5
Ligand
BDBM50198261
Substrate
n/a
Meas. Tech.
ChEMBL_422114 (CHEMBL908799)
IC50
150±n/a nM
Citation
 Jackson, CM; Blass, B; Coburn, K; Djandjighian, L; Fadayel, G; Fluxe, AJ; Hodson, SJ; Janusz, JM; Murawsky, M; Ridgeway, JM; White, RE; Wu, S Evolution of thiazolidine-based blockers of human Kv1.5 for the treatment of atrial arrhythmias. Bioorg Med Chem Lett 17:282-4 (2006) [PubMed]  Article 
Target
Name:
Potassium voltage-gated channel subfamily A member 5
Synonyms:
HK2 | HPCN1 | KCNA5 | KCNA5_HUMAN | Potassium voltage-gated channel subfamily A member 5 | Voltage-gated potassium channel | Voltage-gated potassium channel subunit Kv1.5
Type:
Enzyme
Mol. Mass.:
67222.47
Organism:
Homo sapiens (Human)
Description:
P22460
Residue:
613
Sequence:
MEIALVPLENGGAMTVRGGDEARAGCGQATGGELQCPPTAGLSDGPKEPAPKGRGAQRDADSGVRPLPPLPDPGVRPLPPLPEELPRPRRPPPEDEEEEGDPGLGTVEDQALGTASLHHQRVHINISGLRFETQLGTLAQFPNTLLGDPAKRLRYFDPLRNEYFFDRNRPSFDGILYYYQSGGRLRRPVNVSLDVFADEIRFYQLGDEAMERFREDEGFIKEEEKPLPRNEFQRQVWLIFEYPESSGSARAIAIVSVLVILISIITFCLETLPEFRDERELLRHPPAPHQPPAPAPGANGSGVMAPPSGPTVAPLLPRTLADPFFIVETTCVIWFTFELLVRFFACPSKAGFSRNIMNIIDVVAIFPYFITLGTELAEQQPGGGGGGQNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAEADNQGTHFSSIPDAFWWAVVTMTTVGYGDMRPITVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDHEEPAVLKEEQGTQSQGPGLDRGVQRKVSGSRGSFCKAGGTLENADSARRGSCPLEKCNVKAKSNVDLRRSLYALCLDTSRETDL
  
Inhibitor
Name:
BDBM50198261
Synonyms:
1-(2-(3,4-dimethylphenyl)thiazolidin-3-yl)-3-(4-methoxyphenyl)propan-1-one | CHEMBL262209
Type:
Small organic molecule
Emp. Form.:
C21H25NO2S
Mol. Mass.:
355.494
SMILES:
COc1ccc(CCC(=O)N2CCSC2c2ccc(C)c(C)c2)cc1
Structure:
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