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Target
Melanin-concentrating hormone receptor 1
Ligand
BDBM50199235
Substrate
n/a
Meas. Tech.
ChEMBL_411945 (CHEMBL908393)
IC50
6.1±n/a nM
Citation
 Tavares, FX; Al-Barazanji, KA; Bigham, EC; Bishop, MJ; Britt, CS; Carlton, DL; Feldman, PL; Goetz, AS; Grizzle, MK; Guo, YC; Handlon, AL; Hertzog, DL; Ignar, DM; Lang, DG; Ott, RJ; Peat, AJ; Zhou, HQ Potent, selective, and orally efficacious antagonists of melanin-concentrating hormone receptor 1. J Med Chem 49:7095-107 (2006) [PubMed]  Article 
Target
Name:
Melanin-concentrating hormone receptor 1
Synonyms:
G-protein coupled receptor 24 | GPR24 | MCH receptor 1 | MCH-1R | MCH-R1 | MCHR | MCHR-1 | MCHR1 | MCHR1_HUMAN | Melanin Concentrating Hormone 1 | Melanin-Concentrating Hormone Receptor 1 (MCH1R) | Melanin-concentrating hormone receptor | Melanin-concentrating hormone receptor 1 (MCH-1) | Melanin-concentrating hormone receptor 1 (MCH1) | Melanin-concentrating hormone receptor 1 (MCHR-1) | Melanin-concentrating hormone receptor 1 (MCHR1) | SLC-1 | SLC1 | Somatostatin receptor-like protein
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
45976.27
Organism:
Homo sapiens (Human)
Description:
Membranes from CHO-K1 cells stably expressing human MCH1R were used in assays.
Residue:
422
Sequence:
MSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARLWEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTICLLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESKGT
  
Inhibitor
Name:
BDBM50199235
Synonyms:
6-(4-chlorophenyl)-3-[2-({4-[4-(trifluoromethyl)phenyl]-1-piperidinyl}methyl)-6-quinolinyl]thieno[3,2-d]pyrimidin-4(3H)-one | CHEMBL214468
Type:
Small organic molecule
Emp. Form.:
C34H26ClF3N4OS
Mol. Mass.:
631.11
SMILES:
FC(F)(F)c1ccc(cc1)C1CCN(Cc2ccc3cc(ccc3n2)-n2cnc3cc(sc3c2=O)-c2ccc(Cl)cc2)CC1
Structure:
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