Reaction Details Report a problem with these data
Target
Adenosine receptor A1
Ligand
BDBM50199289
Substrate
n/a
Meas. Tech.
ChEMBL_412202 (CHEMBL910041)
Ki
22±n/a nM
Citation
 Vu, CB; Kiesman, WF; Conlon, PR; Lin, KC; Tam, M; Petter, RC; Smits, G; Lutterodt, F; Jin, X; Chen, L; Zhang, J Tricyclic imidazoline derivatives as potent and selective adenosine A1 receptor antagonists. J Med Chem 49:7132-9 (2006) [PubMed]  Article 
Target
Name:
Adenosine receptor A1
Synonyms:
A1 adenosine receptor (hA1) | A1AR | AA1R_HUMAN | ADENOSINE A1 | ADORA1 | Adenosine A1 receptor (A1AR) | Adenosine A1-receptor | Adenosine receptor A1 (A1) | Adenosine receptor A1 (hA1) | Adenosine transporter (AdT)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36520.92
Organism:
Homo sapiens (Human)
Description:
P30542
Residue:
326
Sequence:
MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVTPRRAAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPSCHKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFLKIWNDHFRCQPAPPIDEDLPEERPDD
  
Inhibitor
Name:
BDBM50199289
Synonyms:
(R)-8-ethyl-2-(4-hydroxybicyclo[2.2.2]octan-1-yl)-4-propyl-7,8-dihydro-1H-imidazo[1,2-g]purin-5(4H)-one | CHEMBL450341
Type:
Small organic molecule
Emp. Form.:
C20H29N5O2
Mol. Mass.:
371.4766
SMILES:
CCCn1c2nc(nc2c2N[C@H](CC)Cn2c1=O)C12CCC(O)(CC1)CC2
Structure:
Search PDB for entries with ligand similarity: