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Target
Type-2 angiotensin II receptor
Ligand
BDBM50199317
Substrate
n/a
Meas. Tech.
ChEMBL_411308 (CHEMBL907246)
Ki
2±n/a nM
Citation
 Wu, X; Wan, Y; Mahalingam, AK; Murugaiah, AM; Plouffe, B; Botros, M; Karlén, A; Hallberg, M; Gallo-Payet, N; Alterman, M Selective angiotensin II AT2 receptor agonists: arylbenzylimidazole structure-activity relationships. J Med Chem 49:7160-8 (2006) [PubMed]  Article 
Target
Name:
Type-2 angiotensin II receptor
Synonyms:
AGTR2 | AGTR2_HUMAN | AT2 | Angiotensin II receptor | Angiotensin II type 2 (AT-2) receptor | Angiotensin II, central | Type-2 angiotensin II receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41201.61
Organism:
Homo sapiens (Human)
Description:
Angiotensin II, central 0 0::P50052
Residue:
363
Sequence:
MKGNSTLATTSKNITSGLHFGLVNISGNNESTLNCSQKPSDKHLDAIPILYYIIFVIGFLVNIVVVTLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWATYYSYRYDWLFGPVMCKVFGSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYIVPLVWCMACLSSLPTFYFRDVRTIEYLGVNACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLKTNSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALAWMGVINSCEVIAVIDLALPFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFRVPITWLQGKRESMSCRKSSSLREMETFVS
  
Inhibitor
Name:
BDBM50199317
Synonyms:
CHEMBL214525 | N-ethyloxycarbonyl-2-(4-imidazol-1-ylmethylphenyl)-4-butylbenzenesulfonamide
Type:
Small organic molecule
Emp. Form.:
C23H27N3O4S
Mol. Mass.:
441.543
SMILES:
CCCCc1ccc(c(c1)-c1ccc(Cn2ccnc2)cc1)S(=O)(=O)NC(=O)OCC
Structure:
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