Reaction Details Report a problem with these data
Target
4-aminobutyrate aminotransferase, mitochondrial
Ligand
BDBM50199991
Substrate
n/a
Meas. Tech.
ChEMBL_422533 (CHEMBL911040)
Ki
2800000±n/a nM
Citation
 Lu, H; Silverman, RB Fluorinated conformationally restricted gamma-aminobutyric acid aminotransferase inhibitors. J Med Chem 49:7404-12 (2006) [PubMed]  Article 
Target
Name:
4-aminobutyrate aminotransferase, mitochondrial
Synonyms:
(S)-3-amino-2-methylpropionate transaminase | 2.6.1.19 | 2.6.1.22 | 4-aminobutyrate aminotransferase, mitochondrial | ABAT | GABA aminotransferase | GABA transaminase | GABA-AT | GABA-T | GABAT | GABT_PIG | Gamma-amino-N-butyrate transaminase | L-AIBAT
Type:
n/a
Mol. Mass.:
56633.06
Organism:
Sus scrofa
Description:
n/a
Residue:
500
Sequence:
MASVLLTRRLACSFRHNHRLLVPGWRHISQAAAKVDVEFDYDGPLMKTEVPGPRSRELMKQLNIIQNAEAVHFFCNYEESRGNYLVDVDGNRMLDLYSQISSIPIGYSHPALVKLVQQPQNVSTFINRPALGILPPENFVEKLRESLLSVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFSKEELETCMINQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFPRLKYPLEEFVKENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRKLRDISRKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFSKKMMTGGFFHKEEFRPNAPYRIFNTWLGDPSKNLLLAEVINIIKREDLLSNAAHAGKVLLTGLLDLQARYPQFISRVRGRGTFCSFDTPDESIRNKLISIARNKGVMLGGCGDKSIRFRPTLVFRDHHAHLFLNIFSDILADFK
  
Inhibitor
Name:
BDBM50199991
Synonyms:
(1R,4S)-4-amino-3-pentafluoroethyl-cyclopent-2-ene carboxylic acid | CHEMBL219258
Type:
Small organic molecule
Emp. Form.:
C8H8F5NO2
Mol. Mass.:
245.1466
SMILES:
N[C@H]1C[C@H](C=C1C(F)(F)C(F)(F)F)C(O)=O |r,c:4|
Structure:
Search PDB for entries with ligand similarity: