Reaction Details Report a problem with these data
Target
Caspase-3
Ligand
BDBM50200302
Substrate
n/a
Meas. Tech.
ChEMBL_408840 (CHEMBL909955)
Ki
1.2±n/a nM
Citation
Kopka, K; Faust, A; Keul, P; Wagner, S; Breyholz, HJ; Höltke, C; Schober, O; Schäfers, M; Levkau, B 5-pyrrolidinylsulfonyl isatins as a potential tool for the molecular imaging of caspases in apoptosis. J Med Chem 49:6704-15 (2006) [PubMed] Article
More Info.:
Target
Name:
Caspase-3
Synonyms:
Apopain | CASP-3 | CASP3 | CASP3_HUMAN | CPP-32 | CPP32 | Caspase 3 | Caspase-3 subunit p12 | Caspase-3 subunit p17 | Cysteine protease CPP32 | SCA-1 | SREBP cleavage activity 1 | Yama protein | caspase-3 preproprotein
Type:
Hydrolase; heterotetramer of two heterodimers
Mol. Mass.:
31607.55
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
277
Sequence:
MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDDDMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH
Inhibitor
Name:
BDBM50200302
Synonyms:
(S)-5-(2-(methoxymethyl)pyrrolidin-1-ylsulfonyl)-1-methylindoline-2,3-dione | (S)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]-1-methylisatin | CHEMBL216819
Type:
Small organic molecule
Emp. Form.:
C15H18N2O5S
Mol. Mass.:
338.379
SMILES:
COC[C@@H]1CCCN1S(=O)(=O)c1ccc2N(C)C(=O)C(=O)c2c1 |r|