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TargetHistamine receptor (H3)
LigandBDBM50200641
Substrate/Competitorn/a
Meas. Tech.ChEMBL_453774
Ki 0.18±n/a nM
Citation Black, LANersesian, DLSharma, PKu, YYBennani, YLMarsh, KCMiller, TREsbenshade, TAHancock, AACowart, M 4-[6-(2-Aminoethyl)naphthalen-2-yl]benzonitriles are potent histamine H3 receptor antagonists with high CNS penetration. Bioorg Med Chem Lett17:1443-6 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Histamine receptor (H3)
Name:Histamine receptor (H3 and H4)
Synonyms:G-protein coupled receptor 97 | HH3R | HISTAMINE H3 | HRH3 | Histamine H3 Receptor | Histamine H3 receptor (H3) | Histamine H3L | Histamine receptor (H3 and H4)
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:48691.47
Organism:Homo sapiens (Human)
Description:Binding assays were using CHO cells stably expressing hH3R receptors.
Residue:445
Sequence:
MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFV
ADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTS
SAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGG
SSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAA
GPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSV
ASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSL
AVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFR
RAFTKLLCPQKLKIQPHSSLEHCWK
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  Blast E-value cutoff:
BDBM50200641
NameBDBM50200641
Synonyms:4-(6-(2-(2-methylpyrrolidin-1-yl)ethyl)naphthalen-2-yl)benzonitrile | CHEMBL395190
TypeSmall organic molecule
Emp. Form.C24H24N2
Mol. Mass.340.4608
SMILESCC1CCCN1CCc1ccc2cc(ccc2c1)-c1ccc(cc1)C#N |w:1.0|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a