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Target
B1 bradykinin receptor
Ligand
BDBM50203207
Substrate
n/a
Meas. Tech.
ChEMBL_425211 (CHEMBL855157)
Ki
382±n/a nM
Citation
 D'Amico, DC; Aya, T; Human, J; Fotsch, C; Chen, JJ; Biswas, K; Riahi, B; Norman, MH; Willoughby, CA; Hungate, R; Reider, PJ; Biddlecome, G; Lester-Zeiner, D; Staden, CV; Johnson, E; Kamassah, A; Arik, L; Wang, J; Viswanadhan, VN; Groneberg, RD; Zhan, J; Suzuki, H; Toro, A; Mareska, DA; Clarke, DE; Harvey, DM; Burgess, LE; Laird, ER; Askew, B; Ng, G Identification of a nonpeptidic and conformationally restricted bradykinin B1 receptor antagonist with anti-inflammatory activity. J Med Chem 50:607-10 (2007) [PubMed]  Article 
Target
Name:
B1 bradykinin receptor
Synonyms:
B1 BRADYKININ | B1 bradykinin receptor | B1R | BDKRB1 | BK-1 receptor | BKRB1_HUMAN | BRADYB1 | Bradykinin B1 receptor
Type:
Enzyme
Mol. Mass.:
40508.87
Organism:
Homo sapiens (Human)
Description:
P46663
Residue:
353
Sequence:
MASSWPPLELQSSNQSQLFPQNATACDNAPEAWDLLHRVLPTFIISICFFGLLGNLFVLLVFLLPRRQLNVAEIYLANLAASDLVFVLGLPFWAENIWNQFNWPFGALLCRVINGVIKANLFISIFLVVAISQDRYRVLVHPMASRRQQRRRQARVTCVLIWVVGGLLSIPTFLLRSIQAVPDLNITACILLLPHEAWHFARIVELNILGFLLPLAAIVFFNYHILASLRTREEVSRTRCGGRKDSKTTALILTLVVAFLVCWAPYHFFAFLEFLFQVQAVRGCFWEDFIDLGLQLANFFAFTNSSLNPVIYVFVGRLFRTKVWELYKQCTPKSLAPISSSHRKEIFQLFWRN
  
Inhibitor
Name:
BDBM50203207
Synonyms:
3-(RS)-N-(4-(piperidin-1-ylmethyl)benzyl)-3-(naphthalene-7-sulfonamido)-3-phenylpropanamide | CHEMBL221691
Type:
Small organic molecule
Emp. Form.:
C32H35N3O3S
Mol. Mass.:
541.704
SMILES:
O=C(CC(NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)NCc1ccc(CN2CCCCC2)cc1
Structure:
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