Reaction Details Report a problem with these data
Target
Neuropeptide Y receptor type 2
Ligand
BDBM50205094
Substrate
n/a
Meas. Tech.
ChEMBL_447170 (CHEMBL897468)
EC50
160±n/a nM
Citation
 DeCarr, LB; Buckholz, TM; Milardo, LF; Mays, MR; Ortiz, A; Lumb, KJ A long-acting selective neuropeptide Y2 receptor PEGylated peptide agonist reduces food intake in mice. Bioorg Med Chem Lett 17:1916-9 (2007) [PubMed]  Article 
Target
Name:
Neuropeptide Y receptor type 2
Synonyms:
NPY-Y2 | NPY-Y2 receptor | NPY2-R | NPY2R | NPY2R_HUMAN | Neuropeptide Y receptor type 2 | Y2 receptor | neuropeptide Y receptor Y2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42734.65
Organism:
Homo sapiens (Human)
Description:
NPY-Y2 NPY2R HUMAN::P49146
Residue:
381
Sequence:
MGPIGAEADENQTVEEMKVEQYGPQTTPRGELVPDPEPELIDSTKLIEVQVVLILAYCSIILLGVIGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAVQVSTITLTVIALDRHRCIVYHLESKISKRISFLIIGLAWGISALLASPLAIFREYSLIEIIPDFEIVACTEKWPGEEKSIYGTVYSLSSLLILYVLPLGIISFSYTRIWSKLKNHVSPGAANDHYHQRRQKTTKMLVCVVVVFAVSWLPLHAFQLAVDIDSQVLDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAFLSAFRCEQRLDAIHSEVSVTFKAKKNLEVRKNSGPNDSFTEATNV
  
Inhibitor
Name:
BDBM50205094
Synonyms:
(S)-2-((S)-2-((2S,3R)-2-((S)-2-((S)-2-((S)-2-((S)-2-((S)-2-((S)-2-((S)-2-((S)-2-acetamido-4-methylpentanamido)-5-guanidinopentanamido)-3-(1H-imidazol-5-yl)propanamido)-3-(4-hydroxyphenyl)propanamido)-4-methylpentanamido)-4-amino-4-oxobutanamido)-4-methylp | CHEMBL393255
Type:
Small organic molecule
Emp. Form.:
C84H136N28O20S
Mol. Mass.:
1890.219
SMILES:
CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CS)C(N)=O |wU:4.4,78.81,45.46,95.96,23.22,61.62,115.116,77.78,wD:33.33,12.11,84.85,53.54,104.105,69.70,127.129,(-16.44,-20.9,;-16.44,-22.44,;-15.11,-23.21,;-17.79,-23.21,;-17.79,-24.75,;-19.12,-25.52,;-20.46,-24.75,;-21.79,-25.52,;-20.46,-23.21,;-16.44,-25.52,;-16.44,-27.06,;-15.12,-24.73,;-13.8,-25.51,;-13.8,-27.05,;-12.45,-27.82,;-12.45,-29.36,;-11.11,-30.11,;-11.12,-31.65,;-12.47,-32.41,;-9.78,-32.42,;-12.45,-24.74,;-12.45,-23.2,;-11.11,-25.49,;-9.77,-24.73,;-9.77,-23.19,;-8.43,-22.42,;-7.03,-23.06,;-5.99,-21.91,;-6.76,-20.58,;-8.27,-20.89,;-8.43,-25.5,;-8.43,-27.04,;-7.11,-24.71,;-5.78,-25.48,;-5.78,-27.02,;-4.44,-27.79,;-3.11,-27.02,;-1.78,-27.79,;-1.78,-29.33,;-.46,-30.08,;-3.11,-30.1,;-4.44,-29.33,;-4.44,-24.71,;-4.44,-23.17,;-3.11,-25.48,;-1.77,-24.71,;-1.77,-23.17,;-.43,-22.4,;-.43,-20.86,;.91,-23.17,;-.43,-25.48,;-.43,-27.02,;.9,-24.71,;2.23,-25.49,;2.23,-27.03,;3.56,-27.8,;4.9,-27.01,;3.56,-29.34,;3.56,-24.72,;3.56,-23.18,;4.9,-25.48,;6.24,-24.71,;6.24,-23.17,;7.58,-22.4,;7.58,-20.86,;8.91,-23.17,;7.58,-25.48,;7.58,-27.02,;8.91,-24.72,;10.25,-25.49,;10.24,-27.03,;11.58,-27.81,;11.57,-29.35,;12.91,-27.04,;11.58,-24.72,;11.58,-23.18,;12.92,-25.49,;14.25,-24.73,;14.25,-23.19,;12.92,-22.42,;15.55,-22.39,;15.59,-25.5,;15.59,-27.04,;16.91,-24.7,;18.23,-25.48,;18.23,-27.02,;19.57,-27.79,;19.57,-29.33,;20.91,-30.09,;20.94,-31.63,;19.57,-32.37,;22.25,-32.38,;19.57,-24.71,;19.57,-23.17,;20.91,-25.47,;22.26,-24.72,;22.26,-23.18,;23.6,-22.41,;23.6,-20.87,;22.25,-20.08,;24.93,-20.1,;23.6,-25.49,;23.6,-27.03,;24.92,-24.71,;26.25,-25.49,;26.25,-27.03,;27.59,-27.8,;27.59,-29.34,;28.93,-30.1,;28.94,-31.64,;27.59,-32.39,;30.27,-32.4,;27.59,-24.72,;27.59,-23.18,;28.92,-25.49,;30.26,-24.72,;30.26,-23.18,;31.6,-22.41,;32.93,-23.18,;34.26,-22.41,;34.26,-20.87,;35.6,-20.1,;32.93,-20.1,;31.6,-20.87,;31.6,-25.49,;31.6,-27.03,;32.93,-24.72,;34.26,-25.49,;34.26,-27.03,;35.6,-27.8,;35.59,-24.72,;36.93,-25.49,;35.59,-23.18,)|
Structure:
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