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Target
C-C chemokine receptor type 5
Ligand
BDBM50205733
Substrate
n/a
Meas. Tech.
ChEMBL_428416 (CHEMBL919486)
EC50
13500±n/a nM
Citation
 Kellenberger, E; Springael, JY; Parmentier, M; Hachet-Haas, M; Galzi, JL; Rognan, D Identification of nonpeptide CCR5 receptor agonists by structure-based virtual screening. J Med Chem 50:1294-303 (2007) [PubMed]  Article 
Target
Name:
C-C chemokine receptor type 5
Synonyms:
C-C CKR-5 | C-C chemokine receptor type 5 | CC-CKR-5 | CCR-5 | CCR5 | CCR5/mu opioid receptor complex | CCR5_HUMAN | CD_antigen=CD195 | CHEMR13 | CMKBR5 | HIV-1 fusion coreceptor
Type:
Enzyme
Mol. Mass.:
40540.21
Organism:
Homo sapiens (Human)
Description:
P51681
Residue:
352
Sequence:
MDYQVSSPIYDINYYTSEPCQKINVKQIAARLLPPLYSLVFIFGFVGNMLVILILINCKRLKSMTDIYLLNLAISDLFFLLTVPFWAHYAAAQWDFGNTMCQLLTGLYFIGFFSGIFFIILLTIDRYLAVVHAVFALKARTVTFGVVTSVITWVVAVFASLPGIIFTRSQKEGLHYTCSSHFPYSQYQFWKNFQTLKIVILGLVLPLLVMVICYSGILKTLLRCRNEKKRHRAVRLIFTIMIVYFLFWAPYNIVLLLNTFQEFFGLNNCSSSNRLDQAMQVTETLGMTHCCINPIIYAFVGEKFRNYLLVFFQKHIAKRFCKCCSIFQQEAPERASSVYTRSTGEQEISVGL
  
Inhibitor
Name:
BDBM50205733
Synonyms:
CHEMBL219769 | N-(1-benzylpiperidin-4-yl)-2-(5-methyl-4-p-tolyl-4H-1,2,4-triazol-3-ylthio)acetamide
Type:
Small organic molecule
Emp. Form.:
C24H29N5OS
Mol. Mass.:
435.585
SMILES:
Cc1nnc(SCC(=O)NC2CCN(Cc3ccccc3)CC2)n1-c1ccc(C)cc1
Structure:
Search PDB for entries with ligand similarity: