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TargetMuscarinic acetylcholine receptor M4
LigandBDBM50206190
Substrate/Competitorn/a
Meas. Tech.ChEMBL_454684
Ki 200±n/a nM
Citation Suckling, CJMurphy, JAKhalaf, AIZhou, SZLizos, DEvan Nhien, ANYasumatsu, HMcVie, AYoung, LCMcCraw, CWaterman, PGMorris, BJPratt, JAHarvey, AL M4 agonists/5HT7 antagonists with potential as antischizophrenic drugs: serominic compounds. Bioorg Med Chem Lett17:2649-55 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Muscarinic acetylcholine receptor M4
Name:Muscarinic acetylcholine receptor M2 and M4
Synonyms:CHRM4 | Cholinergic, muscarinic M4 | Muscarinic acetylcholine receptor
Type:Enzyme Catalytic Domain
Mol. Mass.:53079.31
Organism:Homo sapiens (Human)
Description:Cholinergic, muscarinic M4 CHRM4 HUMAN M3::P08173
Residue:479
Sequence:
MANFTPVNGSSGNQSVRLVTSSSHNRYETVEMVFIATVTGSLSLVTVVGNILVMLSIKVN
RQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASV
MNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTV
PDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAK
TLAFLKSPLMKQSVKKPPPGEAAREELRNGKLEEAPPPALPPPPRPVADKDTSNESSSGS
ATQNTKERPATELSTTEATTPAMPAPPLQPRALNPASRWSKIQIVTKQTGNECVTAIEIV
PATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMV
LVNTFCQSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50206190
NameBDBM50206190
Synonyms:(E)-3-((6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)methyleneamino)-6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-yl acetate | CHEMBL392970
TypeSmall organic molecule
Emp. Form.C25H30N2O4
Mol. Mass.422.5167
SMILESCOc1cc2CCN(Cc2cc1OC)\C=N\c1ccc2CCCCC(OC(C)=O)c2c1 |w:24.26|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a