Reaction Details Report a problem with these data
Target
Lutropin-choriogonadotropic hormone receptor
Ligand
BDBM50206398
Substrate
n/a
Meas. Tech.
ChEMBL_454739 (CHEMBL886762)
EC50
80±n/a nM
Citation
 Jorand-Lebrun, C; Brondyk, B; Lin, J; Magar, S; Murray, R; Reddy, A; Shroff, H; Wands, G; Weiser, W; Xu, Q; McKenna, S; Brugger, N Identification, synthesis, and biological evaluation of novel pyrazoles as low molecular weight luteinizing hormone receptor agonists. Bioorg Med Chem Lett 17:2080-5 (2007) [PubMed]  Article 
Target
Name:
Lutropin-choriogonadotropic hormone receptor
Synonyms:
LCGR | LGR2 | LH/CG-R | LHCGR | LHR | LHRHR | LSH-R | LSHR_HUMAN | Luteinizing hormone receptor
Type:
PROTEIN
Mol. Mass.:
78662.77
Organism:
Homo sapiens (Human)
Description:
ChEMBL_562598
Residue:
699
Sequence:
MKQRFSALQLLKLLLLLQPPLPRALREALCPEPCNCVPDGALRCPGPTAGLTRLSLAYLPVKVIPSQAFRGLNEVIKIEISQIDSLERIEANAFDNLLNLSEILIQNTKNLRYIEPGAFINLPRLKYLSICNTGIRKFPDVTKVFSSESNFILEICDNLHITTIPGNAFQGMNNESVTLKLYGNGFEEVQSHAFNGTTLTSLELKENVHLEKMHNGAFRGATGPKTLDISSTKLQALPSYGLESIQRLIATSSYSLKKLPSRETFVNLLEATLTYPSHCCAFRNLPTKEQNFSHSISENFSKQCESTVRKVNNKTLYSSMLAESELSGWDYEYGFCLPKTPRCAPEPDAFNPCEDIMGYDFLRVLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTKGQYYNHAIDWQTGSGCSTAGFFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAMLPLVGVSNYMKVSICFPMDVETTLSQVYILTILILNVVAFFIICACYIKIYFAVRNPELMATNKDTKIAKKMAILIFTDFTCMAPISFFAISAAFKVPLITVTNSKVLLVLFYPINSCANPFLYAIFTKTFQRDFFLLLSKFGCCKRRAELYRRKDFSAYTSNCKNGFTGSNKPSQSTLKLSTLHCQGTALLDKTRYTEC
  
Inhibitor
Name:
BDBM50206398
Synonyms:
CHEMBL429108 | N-(4-hydroxyphenethyl)-5-(1-(4-tert-butylphenyl)-3-(pyridin-3-yl)-1H-pyrazol-5-yl)pentanamide
Type:
Small organic molecule
Emp. Form.:
C31H36N4O2
Mol. Mass.:
496.6431
SMILES:
CC(C)(C)c1ccc(cc1)-n1nc(cc1CCCCC(=O)NCCc1ccc(O)cc1)-c1cccnc1
Structure:
Search PDB for entries with ligand similarity: