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Target
Cytochrome P450 2D6
Ligand
BDBM50208006
Substrate
n/a
Meas. Tech.
ChEMBL_429178 (CHEMBL913813)
IC50
12000±n/a nM
Citation
 Peretto, I; Forlani, R; Fossati, C; Giardina, GA; Giardini, A; Guala, M; La Porta, E; Petrillo, P; Radaelli, S; Radice, L; Raveglia, LF; Santoro, E; Scudellaro, R; Scarpitta, F; Bigogno, C; Misiano, P; Dondio, GM; Rizzi, A; Armani, E; Amari, G; Civelli, M; Villetti, G; Patacchini, R; Bergamaschi, M; Delcanale, M; Salcedo, C; Fernández, AG; Imbimbo, BP Discovery of diaryl imidazolidin-2-one derivatives, a novel class of muscarinic M3 selective antagonists (Part 1). J Med Chem 50:1571-83 (2007) [PubMed]  Article 
Target
Name:
Cytochrome P450 2D6
Synonyms:
CP2D6_HUMAN | CYP2D6 | CYP2DL1 | CYPIID6 | Cytochrome P450 2D6 (CYP2D6) | Debrisoquine 4-hydroxylase | P450-DB1
Type:
Protein
Mol. Mass.:
55774.82
Organism:
Homo sapiens (Human)
Description:
P10635
Residue:
497
Sequence:
MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVSPSPYELCAVPR
  
Inhibitor
Name:
BDBM50208006
Synonyms:
3-(1-(3-fluorobenzyl)-piperidin-4-yl)-5,5-di-(4-fluorophenyl)-imidazolidin-2-one | CHEMBL221401
Type:
Small organic molecule
Emp. Form.:
C27H26F3N3O
Mol. Mass.:
465.51
SMILES:
Fc1ccc(cc1)C1(CN(C2CCN(Cc3cccc(F)c3)CC2)C(=O)N1)c1ccc(F)cc1
Structure:
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