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TargetMuscarinic acetylcholine receptor M2
LigandBDBM50208014
Substrate/Competitorn/a
Meas. Tech.ChEMBL_429169
Ki 65±n/a nM
Citation Peretto, IForlani, RFossati, CGiardina, GAGiardini, AGuala, MLa Porta, EPetrillo, PRadaelli, SRadice, LRaveglia, LFSantoro, EScudellaro, RScarpitta, FBigogno, CMisiano, PDondio, GMRizzi, AArmani, EAmari, GCivelli, MVilletti, GPatacchini, RBergamaschi, MDelcanale, MSalcedo, CFernández, AGImbimbo, BP Discovery of diaryl imidazolidin-2-one derivatives, a novel class of muscarinic M3 selective antagonists (Part 1). J Med Chem50:1571-83 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Muscarinic acetylcholine receptor M2
Name:Muscarinic acetylcholine receptor M2 and M5
Synonyms:CHRM2 | Cholinergic, muscarinic M2 | RecName: Full=Muscarinic acetylcholine receptor M2
Type:GPCR
Mol. Mass.:51730.61
Organism:Homo sapiens (Human)
Description:P08172
Residue:466
Sequence:
MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNY
FLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFD
RYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQF
FSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRI
VKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDE
ITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNI
VARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNT
VWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50208014
NameBDBM50208014
Synonyms:3-(1-benzyl-tropin-4-yl)-5,5-diphenyl-imidazolidin-2-one | CHEMBL221400
TypeSmall organic molecule
Emp. Form.C29H31N3O
Mol. Mass.437.5759
SMILESO=C1NC(CN1C1CC2CCC(C1)N2Cc1ccccc1)(c1ccccc1)c1ccccc1 |TLB:5:6:13:9.10|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
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