Reaction Details Report a problem with these data
Target
Muscarinic acetylcholine receptor M3
Ligand
BDBM50208049
Substrate
n/a
Meas. Tech.
ChEMBL_429188 (CHEMBL913822)
Ki
2535±n/a nM
Citation
 Peretto, I; Fossati, C; Giardina, GA; Giardini, A; Guala, M; La Porta, E; Petrillo, P; Radaelli, S; Radice, L; Raveglia, LF; Santoro, E; Scudellaro, R; Scarpitta, F; Cerri, A; Menegon, S; Dondio, GM; Rizzi, A; Armani, E; Amari, G; Civelli, M; Villetti, G; Patacchini, R; Bergamaschi, M; Bassani, F; Delcanale, M; Imbimbo, BP Discovery of diaryl imidazolidin-2-one derivatives, a novel class of muscarinic M3 selective antagonists (Part 2). J Med Chem 50:1693-7 (2007) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M3
Synonyms:
ACM3_HUMAN | CHRM3 | Cholinergic, muscarinic M3 | Muscarinic Receptors M3 | Muscarinic receptor M3 | RecName: Full=Muscarinic acetylcholine receptor M3
Type:
Enzyme
Mol. Mass.:
66151.03
Organism:
Homo sapiens (Human)
Description:
P20309
Residue:
590
Sequence:
MTLHNNSTTSPLFPNISSSWIHSPSDAGLPPGTVTHFGSYNVSRAAGNFSSPDGTTDDPLGGHTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFYMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSMKRSNRRKYGRCHFWFTTKSWKPSSEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSETRAIYSIVLKLPGHSTILNSTKLPSSDNLQVPEEELGMVDLERKADKLQAQKSVDDGGSFPKSFSKLPIQLESAVDTAKTSDVNSSVGKSTATLPLSFKEATLAKRFALKTRSQITKRKRMSLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTFWNLGYWLCYINSTVNPVCYALCNKTFRTTFKMLLLCQCDKKKRRKQQYQQRQSVIFHKRAPEQAL
  
Inhibitor
Name:
BDBM50208049
Synonyms:
8-benzyl-8-methyl-3-(2-oxo-4,4-diphenyl-imidazolidin-1-yl)-8-azonia-bicyclo[3.2.1]octane | CHEMBL224965
Type:
Small organic molecule
Emp. Form.:
C30H34N3O
Mol. Mass.:
452.6099
SMILES:
C[N+]1(Cc2ccccc2)C2CCC1CC(C2)N1CC(NC1=O)(c1ccccc1)c1ccccc1 |TLB:2:1:14.15.13:10.11,THB:0:1:14.15.13:10.11,(3.03,-8.76,;2.59,-7.29,;3.91,-6.51,;5.25,-7.26,;5.26,-8.8,;6.6,-9.56,;7.93,-8.78,;7.91,-7.23,;6.56,-6.48,;1.8,-5.94,;2.24,-4.34,;1.4,-5.42,;1.3,-6.89,;-.33,-7.54,;-1.12,-6.18,;.07,-6.59,;-2.58,-6.65,;-3.06,-8.12,;-4.6,-8.12,;-5.07,-6.65,;-3.83,-5.75,;-3.84,-4.21,;-3.89,-9.48,;-4.73,-10.78,;-4.02,-12.14,;-2.48,-12.21,;-1.66,-10.91,;-2.37,-9.54,;-6.15,-8.12,;-6.92,-6.77,;-8.47,-6.77,;-9.24,-8.11,;-8.46,-9.46,;-6.92,-9.45,)|
Structure:
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