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Target
Muscarinic acetylcholine receptor M3
Ligand
BDBM50208051
Substrate
n/a
Meas. Tech.
ChEMBL_429188 (CHEMBL913822)
Ki
1.84±n/a nM
Citation
 Peretto, I; Fossati, C; Giardina, GA; Giardini, A; Guala, M; La Porta, E; Petrillo, P; Radaelli, S; Radice, L; Raveglia, LF; Santoro, E; Scudellaro, R; Scarpitta, F; Cerri, A; Menegon, S; Dondio, GM; Rizzi, A; Armani, E; Amari, G; Civelli, M; Villetti, G; Patacchini, R; Bergamaschi, M; Bassani, F; Delcanale, M; Imbimbo, BP Discovery of diaryl imidazolidin-2-one derivatives, a novel class of muscarinic M3 selective antagonists (Part 2). J Med Chem 50:1693-7 (2007) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M3
Synonyms:
ACM3_HUMAN | CHRM3 | Cholinergic, muscarinic M3 | Muscarinic Receptors M3 | Muscarinic receptor M3 | RecName: Full=Muscarinic acetylcholine receptor M3
Type:
Enzyme
Mol. Mass.:
66151.03
Organism:
Homo sapiens (Human)
Description:
P20309
Residue:
590
Sequence:
MTLHNNSTTSPLFPNISSSWIHSPSDAGLPPGTVTHFGSYNVSRAAGNFSSPDGTTDDPLGGHTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFYMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSMKRSNRRKYGRCHFWFTTKSWKPSSEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSETRAIYSIVLKLPGHSTILNSTKLPSSDNLQVPEEELGMVDLERKADKLQAQKSVDDGGSFPKSFSKLPIQLESAVDTAKTSDVNSSVGKSTATLPLSFKEATLAKRFALKTRSQITKRKRMSLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTFWNLGYWLCYINSTVNPVCYALCNKTFRTTFKMLLLCQCDKKKRRKQQYQQRQSVIFHKRAPEQAL
  
Inhibitor
Name:
BDBM50208051
Synonyms:
1-methyl-3-(R)-3-[4,4-bis-(4-fluoro-phenyl)-2-oxo-imidazolidin-1-yl]-1-(2-oxo-2-phenyl-ethyl)-pyrrolidinium | CHEMBL374513
Type:
Small organic molecule
Emp. Form.:
C28H28F2N3O2
Mol. Mass.:
476.5371
SMILES:
C[N+]1(CC(=O)c2ccccc2)CC[C@H](C1)N1CC(NC1=O)(c1ccc(F)cc1)c1ccc(F)cc1
Structure:
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