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TargetMuscarinic acetylcholine receptor M3
LigandBDBM50208058
Substrate/Competitorn/a
Meas. Tech.ChEMBL_429188
Ki 1.89±n/a nM
Citation Peretto, IFossati, CGiardina, GAGiardini, AGuala, MLa Porta, EPetrillo, PRadaelli, SRadice, LRaveglia, LFSantoro, EScudellaro, RScarpitta, FCerri, AMenegon, SDondio, GMRizzi, AArmani, EAmari, GCivelli, MVilletti, GPatacchini, RBergamaschi, MBassani, FDelcanale, MImbimbo, BP Discovery of diaryl imidazolidin-2-one derivatives, a novel class of muscarinic M3 selective antagonists (Part 2). J Med Chem50:1693-7 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Muscarinic acetylcholine receptor M3
Name:Muscarinic acetylcholine receptor M1 and M3
Synonyms:CHRM3 | Cholinergic, muscarinic M3 | Muscarinic Receptors M3 | Muscarinic receptor M3 | RecName: Full=Muscarinic acetylcholine receptor M3
Type:Enzyme
Mol. Mass.:66151.03
Organism:Homo sapiens (Human)
Description:P20309
Residue:590
Sequence:
MTLHNNSTTSPLFPNISSSWIHSPSDAGLPPGTVTHFGSYNVSRAAGNFSSPDGTTDDPL
GGHTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVI
SMNLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKR
TTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAF
YMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSM
KRSNRRKYGRCHFWFTTKSWKPSSEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSE
TRAIYSIVLKLPGHSTILNSTKLPSSDNLQVPEEELGMVDLERKADKLQAQKSVDDGGSF
PKSFSKLPIQLESAVDTAKTSDVNSSVGKSTATLPLSFKEATLAKRFALKTRSQITKRKR
MSLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTFWNLGYWLCYINSTVN
PVCYALCNKTFRTTFKMLLLCQCDKKKRRKQQYQQRQSVIFHKRAPEQAL
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BDBM50208058
NameBDBM50208058
Synonyms:1-methyl-3-(2-oxo-4,4-diphenyl-imidazolidin-1-yl)-1-(2-oxo-2-phenyl-ethyl)-pyrrolidinium | CHEMBL222636
TypeSmall organic molecule
Emp. Form.C28H30N3O2
Mol. Mass.440.5562
SMILESC[N+]1(CC(=O)c2ccccc2)CCC(C1)N1CC(NC1=O)(c1ccccc1)c1ccccc1
Structure
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n/a