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TargetHM74 nicotinic acid GPCR
LigandBDBM50208125
Substrate/Competitorn/a
Meas. Tech.ChEMBL_429282
EC50 4800±n/a nM
Citation Jung, JKJohnson, BRDuong, TDecaire, MUy, JGharbaoui, TBoatman, PDSage, CRChen, RRichman, JGConnolly, DTSemple, G Analogues of acifran: agonists of the high and low affinity niacin receptors, GPR109a and GPR109b. J Med Chem50:1445-8 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
HM74 nicotinic acid GPCR
Name:HM74 nicotinic acid GPCR
Synonyms:G-protein coupled receptor 109B | G-protein coupled receptor HM74 | G-protein coupled receptor HM74B | HCA3 | HCAR3 | HM74B | Hydroxycarboxylic acid receptor 3 | NIACR2 | Niacin receptor 2 | Nicotinic acid receptor 2
Type:Enzyme Catalytic Domain
Mol. Mass.:44498.06
Organism:Homo sapiens (Human)
Description:GPR109B 0 HUMAN::P49019
Residue:387
Sequence:
MNRHHLQDHFLEIDKKNCCVFRDDFIAKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWK
SSRIFLFNLAVADFLLIICLPFVMDYYVRRSDWKFGDIPCRLVLFMFAMNRQGSIIFLTV
VAVDRYFRVVHPHHALNKISNWTAAIISCLLWGITVGLTVHLLKKKLLIQNGTANVCISF
SICHTFRWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVF
VICFLPSVVVRIHIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPS
FPNFFSTLINRCLQRKITGEPDNNRSTSVELTGDPNKTRGAPEALIANSGEPWSPSYLGP
TSNNHSKKGHCHQEPASLEKQLGCCIE
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50208125
NameBDBM50208125
Synonyms:5-ethyl-4-oxo-5-phenyl-4,5-dihydro-furan-2-carboxylic acid | CHEMBL436301
TypeSmall organic molecule
Emp. Form.C13H12O4
Mol. Mass.232.232
SMILESCCC1(OC(=CC1=O)C(O)=O)c1ccccc1 |c:4|
Structure
n/a