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Target
P2Y purinoceptor 14
Ligand
BDBM50209663
Substrate
n/a
Meas. Tech.
ChEMBL_434326 (CHEMBL917907)
EC50
350±n/a nM
Citation
 Ko, H; Fricks, I; Ivanov, AA; Harden, TK; Jacobson, KA Structure-activity relationship of uridine 5'-diphosphoglucose analogues as agonists of the human P2Y14 receptor. J Med Chem 50:2030-9 (2007) [PubMed]  Article 
Target
Name:
P2Y purinoceptor 14
Synonyms:
GPR105 | Insulin Receptor-Related Protein (INSRR) | KIAA0001 | P2RY14 | P2Y14_HUMAN | Purinergic receptor P2Y14
Type:
PROTEIN
Mol. Mass.:
38991.62
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1502487
Residue:
338
Sequence:
MINSTSTQPPDESCSQNLLITQQIIPVLYCMVFIAGILLNGVSGWIFFYVPSSKSFIIYLKNIVIADFVMSLTFPFKILGDSGLGPWQLNVFVCRVSAVLFYVNMYVSIVFFGLISFDRYYKIVKPLWTSFIQSVSYSKLLSVIVWMLMLLLAVPNIILTNQSVREVTQIKCIELKSELGRKWHKASNYIFVAIFWIVFLLLIVFYTAITKKIFKSHLKSSRNSTSVKKKSSRNIFSIVFVFFVCFVPYHIARIPYTKSQTEAHYSCQSKEILRYMKEFTLLLSAANVCLDPIIYFFLCQPFREILCKKLHIPLKAQNDLDISRIKRGNTTLESTDTL
  
Inhibitor
Name:
BDBM50209663
Synonyms:
CHEMBL374384 | MRS-2670 | diphosphoric acid 1-alpha-D-glucopyranosyl ester 2-((4'-thio)uridin-5''-yl) ester
Type:
Small organic molecule
Emp. Form.:
C15H24N2O16P2S
Mol. Mass.:
582.367
SMILES:
OC[C@H]1O[C@H](OP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)n2ccc(=S)[nH]c2=O)[C@H](O)[C@@H](O)[C@@H]1O
Structure:
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