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Target
B1 bradykinin receptor
Ligand
BDBM50210358
Substrate
n/a
Meas. Tech.
ChEMBL_443978 (CHEMBL893140)
Ki
1645±n/a nM
Citation
 Su, DS; Lim, JL; Markowitz, MK; Wan, BL; Murphy, KL; Reiss, DR; Harrell, CM; O'Malley, SS; Ransom, RW; Chang, RS; Pettibone, DJ; Tang, C; Prueksaritanont, T; Freidinger, RM; Bock, MG Potent bradykinin B1 receptor antagonists: 4-substituted phenyl cyclohexanes. Bioorg Med Chem Lett 17:3006-9 (2007) [PubMed]  Article 
Target
Name:
B1 bradykinin receptor
Synonyms:
B1 BRADYKININ | B1 bradykinin receptor | B1R | BDKRB1 | BK-1 receptor | BKRB1_HUMAN | BRADYB1 | Bradykinin B1 receptor
Type:
Enzyme
Mol. Mass.:
40508.87
Organism:
Homo sapiens (Human)
Description:
P46663
Residue:
353
Sequence:
MASSWPPLELQSSNQSQLFPQNATACDNAPEAWDLLHRVLPTFIISICFFGLLGNLFVLLVFLLPRRQLNVAEIYLANLAASDLVFVLGLPFWAENIWNQFNWPFGALLCRVINGVIKANLFISIFLVVAISQDRYRVLVHPMASRRQQRRRQARVTCVLIWVVGGLLSIPTFLLRSIQAVPDLNITACILLLPHEAWHFARIVELNILGFLLPLAAIVFFNYHILASLRTREEVSRTRCGGRKDSKTTALILTLVVAFLVCWAPYHFFAFLEFLFQVQAVRGCFWEDFIDLGLQLANFFAFTNSSLNPVIYVFVGRLFRTKVWELYKQCTPKSLAPISSSHRKEIFQLFWRN
  
Inhibitor
Name:
BDBM50210358
Synonyms:
CHEMBL233873 | methyl 1-phenyl-4-((3-(3,3,3-trifluoropropanamido)pyridin-2-ylamino)methyl)cyclohexanecarboxylate
Type:
Small organic molecule
Emp. Form.:
C23H26F3N3O3
Mol. Mass.:
449.466
SMILES:
COC(=O)C1(CCC(CNc2ncccc2NC(=O)CC(F)(F)F)CC1)c1ccccc1 |(2.14,6.38,;2.11,4.85,;.77,4.1,;-.55,4.89,;.74,2.56,;.74,1.01,;-.6,.24,;-1.93,1.01,;-3.26,.24,;-3.26,-1.3,;-4.6,-2.06,;-4.6,-3.6,;-5.93,-4.37,;-7.26,-3.6,;-7.26,-2.06,;-5.93,-1.29,;-5.94,.25,;-7.27,1.02,;-8.6,.25,;-7.27,2.56,;-8.6,3.33,;-9.94,4.1,;-7.83,4.67,;-9.37,2,;-1.93,2.56,;-.6,3.33,;2.08,1.82,;2.12,.28,;3.47,-.45,;4.8,.35,;4.76,1.89,;3.4,2.62,)|
Structure:
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