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Target
B1 bradykinin receptor
Ligand
BDBM50210362
Substrate
n/a
Meas. Tech.
ChEMBL_443978 (CHEMBL893140)
Ki
30±n/a nM
Citation
 Su, DS; Lim, JL; Markowitz, MK; Wan, BL; Murphy, KL; Reiss, DR; Harrell, CM; O'Malley, SS; Ransom, RW; Chang, RS; Pettibone, DJ; Tang, C; Prueksaritanont, T; Freidinger, RM; Bock, MG Potent bradykinin B1 receptor antagonists: 4-substituted phenyl cyclohexanes. Bioorg Med Chem Lett 17:3006-9 (2007) [PubMed]  Article 
Target
Name:
B1 bradykinin receptor
Synonyms:
B1 BRADYKININ | B1 bradykinin receptor | B1R | BDKRB1 | BK-1 receptor | BKRB1_HUMAN | BRADYB1 | Bradykinin B1 receptor
Type:
Enzyme
Mol. Mass.:
40508.87
Organism:
Homo sapiens (Human)
Description:
P46663
Residue:
353
Sequence:
MASSWPPLELQSSNQSQLFPQNATACDNAPEAWDLLHRVLPTFIISICFFGLLGNLFVLLVFLLPRRQLNVAEIYLANLAASDLVFVLGLPFWAENIWNQFNWPFGALLCRVINGVIKANLFISIFLVVAISQDRYRVLVHPMASRRQQRRRQARVTCVLIWVVGGLLSIPTFLLRSIQAVPDLNITACILLLPHEAWHFARIVELNILGFLLPLAAIVFFNYHILASLRTREEVSRTRCGGRKDSKTTALILTLVVAFLVCWAPYHFFAFLEFLFQVQAVRGCFWEDFIDLGLQLANFFAFTNSSLNPVIYVFVGRLFRTKVWELYKQCTPKSLAPISSSHRKEIFQLFWRN
  
Inhibitor
Name:
BDBM50210362
Synonyms:
CHEMBL234514 | N-(2-((4-cyano-4-(3,4-dichlorophenyl)cyclohexyl)methylamino)pyridin-3-yl)-3,3,3-trifluoropropanamide
Type:
Small organic molecule
Emp. Form.:
C22H21Cl2F3N4O
Mol. Mass.:
485.33
SMILES:
FC(F)(F)CC(=O)Nc1cccnc1NCC1CCC(CC1)(C#N)c1ccc(Cl)c(Cl)c1 |(9.91,3.48,;11.24,2.71,;12.01,4.05,;10.48,1.38,;12.57,1.94,;12.57,.41,;11.24,-.36,;13.9,-.38,;13.91,-1.92,;12.58,-2.68,;12.58,-4.22,;13.91,-4.99,;15.25,-4.22,;15.25,-2.68,;16.57,-1.89,;17.9,-1.12,;19.25,-1.88,;19.26,-3.42,;20.59,-4.19,;21.95,-3.38,;21.92,-1.84,;20.57,-1.09,;23.22,-2.52,;24.48,-1.64,;22.71,-4.71,;24.25,-4.72,;25.02,-6.05,;24.25,-7.38,;25.01,-8.71,;22.71,-7.38,;21.94,-8.71,;21.93,-6.04,)|
Structure:
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