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Target
B1 bradykinin receptor
Ligand
BDBM50210370
Substrate
n/a
Meas. Tech.
ChEMBL_443978 (CHEMBL893140)
Ki
2±n/a nM
Citation
 Su, DS; Lim, JL; Markowitz, MK; Wan, BL; Murphy, KL; Reiss, DR; Harrell, CM; O'Malley, SS; Ransom, RW; Chang, RS; Pettibone, DJ; Tang, C; Prueksaritanont, T; Freidinger, RM; Bock, MG Potent bradykinin B1 receptor antagonists: 4-substituted phenyl cyclohexanes. Bioorg Med Chem Lett 17:3006-9 (2007) [PubMed]  Article 
Target
Name:
B1 bradykinin receptor
Synonyms:
B1 BRADYKININ | B1 bradykinin receptor | B1R | BDKRB1 | BK-1 receptor | BKRB1_HUMAN | BRADYB1 | Bradykinin B1 receptor
Type:
Enzyme
Mol. Mass.:
40508.87
Organism:
Homo sapiens (Human)
Description:
P46663
Residue:
353
Sequence:
MASSWPPLELQSSNQSQLFPQNATACDNAPEAWDLLHRVLPTFIISICFFGLLGNLFVLLVFLLPRRQLNVAEIYLANLAASDLVFVLGLPFWAENIWNQFNWPFGALLCRVINGVIKANLFISIFLVVAISQDRYRVLVHPMASRRQQRRRQARVTCVLIWVVGGLLSIPTFLLRSIQAVPDLNITACILLLPHEAWHFARIVELNILGFLLPLAAIVFFNYHILASLRTREEVSRTRCGGRKDSKTTALILTLVVAFLVCWAPYHFFAFLEFLFQVQAVRGCFWEDFIDLGLQLANFFAFTNSSLNPVIYVFVGRLFRTKVWELYKQCTPKSLAPISSSHRKEIFQLFWRN
  
Inhibitor
Name:
BDBM50210370
Synonyms:
CHEMBL388031 | N-(2-((4-cyano-4-(2,3-difluorophenyl)cyclohexyl)methylamino)pyridin-3-yl)-3,3,3-trifluoropropanamide
Type:
Small organic molecule
Emp. Form.:
C22H21F5N4O
Mol. Mass.:
452.4204
SMILES:
Fc1cccc(c1F)C1(CCC(CNc2ncccc2NC(=O)CC(F)(F)F)CC1)C#N |(1.61,-8.98,;2.34,-7.63,;3.88,-7.58,;4.61,-6.23,;3.79,-4.92,;2.26,-4.96,;1.52,-6.32,;-.02,-6.37,;1.45,-3.66,;.09,-4.47,;-1.23,-3.7,;-1.25,-2.15,;-2.6,-1.39,;-3.92,-2.17,;-5.25,-2.95,;-5.25,-4.5,;-6.58,-5.27,;-7.92,-4.5,;-7.92,-2.95,;-6.58,-2.18,;-6.59,-.64,;-7.92,.14,;-9.25,-.63,;-7.92,1.68,;-9.25,2.44,;-10.59,3.21,;-8.49,3.78,;-10.02,1.11,;.08,-1.37,;1.42,-2.12,;2.72,-2.79,;3.98,-1.92,)|
Structure:
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