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Target
5-hydroxytryptamine receptor 7
Ligand
BDBM50213546
Substrate
n/a
Meas. Tech.
ChEMBL_456155 (CHEMBL888166)
Ki
0.9±n/a nM
Citation
 Leopoldo, M; Lacivita, E; Colabufo, NA; Niso, M; Berardi, F; Perrone, R Bivalent ligand approach on 4-[2-(3-methoxyphenyl)ethyl]-1-(2-methoxyphenyl)piperazine: synthesis and binding affinities for 5-HT(7) and 5-HT(1A) receptors. Bioorg Med Chem 15:5316-21 (2007) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 7
Synonyms:
5-HT-7 | 5-HT-X | 5-HT7 | 5-HT7L | 5-HT7S | 5-Hydroxytryptamine receptor 7 (5-HT7) | 5-hydroxytryptamine receptor 7 | 5-hydroxytryptamine receptor 7 (5-HT-7) | 5HT7R_RAT | Adrenergic Alpha | GPRFO | Htr7 | Serotonin (5-HT) receptor | Serotonin Receptor 7
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
49852.62
Organism:
Rattus norvegicus (rat)
Description:
Rat cloned 5-HT7R.
Residue:
448
Sequence:
MMDVNSSGRPDLYGHLRSLILPEVGRGLQDLSPDGGAHPVVSSWMPHLLSGFLEVTASPAPTWDAPPDNVSGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVQPESVISLNGVVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTCLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERSEFVLQNSDHCGKKGHDT
  
Inhibitor
Name:
BDBM50213546
Synonyms:
1,4-bis-[3-[2-[4-(2-methoxyphenyl)piperazin-1-yl]-ethyl]phenoxy]butane | CHEMBL239656
Type:
Small organic molecule
Emp. Form.:
C42H54N4O4
Mol. Mass.:
678.9026
SMILES:
COc1ccccc1N1CCN(CCc2cccc(OCCCCOc3cccc(CCN4CCN(CC4)c4ccccc4OC)c3)c2)CC1
Structure:
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