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Target
Transcription factor Jun
Ligand
BDBM50213936
Substrate
n/a
Meas. Tech.
ChEMBL_456206 (CHEMBL888216)
IC50
>300±n/a nM
Citation
 Gao, W; Bussom, S; Grill, SP; Gullen, EA; Hu, YC; Huang, X; Zhong, S; Kaczmarek, C; Gutierrez, J; Francis, S; Baker, DC; Yu, S; Cheng, YC Structure-activity studies of phenanthroindolizidine alkaloids as potential antitumor agents. Bioorg Med Chem Lett 17:4338-42 (2007) [PubMed]  Article 
Target
Name:
Transcription factor Jun
Synonyms:
AP1 | Activator protein 1 | JUN | JUN_HUMAN | Proto-oncogene c-JUN | Transcription factor AP-1 | Transcription factor AP1 | V-jun avian sarcoma virus 17 oncogene homolog | p39
Type:
n/a
Mol. Mass.:
35683.24
Organism:
Homo sapiens (Human)
Description:
P05412
Residue:
331
Sequence:
MTAKMETTFYDDALNASFLPSESGPYGYSNPKILKQSMTLNLADPVGSLKPHLRAKNSDLLTSPDVGLLKLASPELERLIIQSSNGHITTTPTPTQFLCPKNVTDEQEGFAEGFVRALAELHSQNTLPSVTSAAQPVNGAGMVAPAVASVAGGSGSGGFSASLHSEPPVYANLSNFNPGALSSGGGAPSYGAAGLAFPAQPQQQQQPPHHLPQQMPVQHPRLQALKEEPQTVPEMPGETPPLSPIDMESQERIKAERKRMRNRIAASKCRKRKLERIARLEEKVKTLKAQNSELASTANMLREQVAQLKQKVMNHVNSGCQLMLTQQLQTF
  
Inhibitor
Name:
BDBM50213936
Synonyms:
(S)-2,3,6,7-tetramethoxy-8b,9,10,11,12,12a-hexahydro-9a-aza-cyclopenta[b]triphenylene | CHEMBL399317
Type:
Small organic molecule
Emp. Form.:
C24H27NO4
Mol. Mass.:
393.4755
SMILES:
COc1cc2C3CN4CCC[C@H]4C=C3c3cc(OC)c(OC)cc3-c2cc1OC |w:5.5,c:13|
Structure:
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