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Target
Casein kinase II subunit alpha
Ligand
BDBM50214478
Substrate
n/a
Meas. Tech.
ChEMBL_439082 (CHEMBL889430)
Ki
55±n/a nM
Citation
 Nie, Z; Perretta, C; Erickson, P; Margosiak, S; Almassy, R; Lu, J; Averill, A; Yager, KM; Chu, S Structure-based design, synthesis, and study of pyrazolo[1,5-a][1,3,5]triazine derivatives as potent inhibitors of protein kinase CK2. Bioorg Med Chem Lett 17:4191-5 (2007) [PubMed]  Article 
Target
Name:
Casein kinase II subunit alpha
Synonyms:
CK II | CK2 | CK2- alpha | CK2A1 | CSK21_HUMAN | CSNK2A1 | Casein kinase 2 | Casein kinase II (CK2) | Casein kinase II alpha/beta | Casein kinase II subunit alpha (CK2 alpha) | Casein kinase II subunit alpha (CK2A1) | Casein kinase II subunit alpha (CK2a I174A) | Casein kinase II subunit alpha (CK2a V66A) | Casein kinase II subunit alpha (CK2a dm V66I174AA) | Casein kinase II subunit alpha (CK2a)
Type:
Enzyme
Mol. Mass.:
45151.12
Organism:
Homo sapiens (Human)
Description:
P68400
Residue:
391
Sequence:
MSGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMGSSSMPGGSTPVSSANMMSGISSVPTPSPLGPLAGSPVIAAANPLGMPVPAAAGAQQ
  
Inhibitor
Name:
BDBM50214478
Synonyms:
2-(benzyl(methyl)amino)-4-(phenylamino)pyrazolo[1,5-a][1,3,5]triazine-8-carbonitrile | CHEMBL230455
Type:
Small organic molecule
Emp. Form.:
C20H17N7
Mol. Mass.:
355.3959
SMILES:
CN(Cc1ccccc1)c1nc(Nc2ccccc2)n2ncc(C#N)c2n1
Structure:
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