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Target
Peroxisome proliferator-activated receptor delta
Ligand
BDBM50214964
Substrate
n/a
Meas. Tech.
ChEMBL_447651 (CHEMBL896658)
EC50
3900±n/a nM
Citation
 Havranek, M; Sauerberg, P; Mogensen, JP; Kratina, P; Jeppesen, CB; Pettersson, I; Pihera, P Novel selective PPARdelta agonists: optimization of activity by modification of alkynylallylic moiety. Bioorg Med Chem Lett 17:4144-9 (2007) [PubMed]  Article 
Target
Name:
Peroxisome proliferator-activated receptor delta
Synonyms:
NR1C2 | NUC1 | NUCI | Nuclear hormone receptor 1 | Nuclear receptor subfamily 1 group C member 2 | PPAR delta | PPAR-beta | PPARB | PPARD | PPARD_HUMAN | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor beta | Peroxisome proliferator-activated receptor delta
Type:
Enzyme
Mol. Mass.:
49910.45
Organism:
Homo sapiens (Human)
Description:
Q03181
Residue:
441
Sequence:
MEQPQEEAPEVREEEEKEEVAEAEGAPELNGGPQHALPSSSYTDLSRSSSPPSLLDQLQMGCDGASCGSLNMECRVCGDKASGFHYGVHACEGCKGFFRRTIRMKLEYEKCERSCKIQKKNRNKCQYCRFQKCLALGMSHNAIRFGRMPEAEKRKLVAGLTANEGSQYNPQVADLKAFSKHIYNAYLKNFNMTKKKARSILTGKASHTAPFVIHDIETLWQAEKGLVWKQLVNGLPPYKEISVHVFYRCQCTTVETVRELTEFAKSIPSFSSLFLNDQVTLLKYGVHEAIFAMLASIVNKDGLLVANGSGFVTREFLRSLRKPFSDIIEPKFEFAVKFNALELDDSDLALFIAAIILCGDRPGLMNVPRVEAIQDTILRALEFHLQANHPDAQYLFPKLLQKMADLRQLVTEHAQMMQRIKKTETETSLHPLLQEIYKDMY
  
Inhibitor
Name:
BDBM50214964
Synonyms:
(Z)-2-(2-methyl-4-(4-(4-(5-methylthiophen-2-yl)phenyl)-6-phenylhex-2-en-5-ynyloxy)phenoxy)acetic acid | CHEMBL234906
Type:
Small organic molecule
Emp. Form.:
C32H28O4S
Mol. Mass.:
508.627
SMILES:
Cc1ccc(s1)-c1ccc(cc1)C(\C=C/COc1ccc(OCC(O)=O)c(C)c1)C#Cc1ccccc1 |w:12.14|
Structure:
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