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Target
Disintegrin and metalloproteinase domain-containing protein 17
Ligand
BDBM50215994
Substrate
n/a
Meas. Tech.
ChEMBL_456574 (CHEMBL922940)
IC50
28±n/a nM
Citation
 Gilmore, JL; King, BW; Asakawa, N; Harrison, K; Tebben, A; Sheppeck, JE; Liu, RQ; Covington, M; Duan, JJ Synthesis and structure-activity relationship of a novel, non-hydroxamate series of TNF-alpha converting enzyme inhibitors. Bioorg Med Chem Lett 17:4678-82 (2007) [PubMed]  Article 
Target
Name:
Disintegrin and metalloproteinase domain-containing protein 17
Synonyms:
A disintegrin and metalloproteinase domain 17 | ADA17_PIG | ADAM 17 | ADAM17 | Snake venom-like protease | TACE | TNF-alpha-Converting Enzyme
Type:
Metalloprotease
Mol. Mass.:
12197.99
Organism:
Sus scrofa (pig)
Description:
Partially purified TACE was obtained from porcine spleen.
Residue:
112
Sequence:
MLREQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANSHGGVCPKAYYSPIGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNE
  
Inhibitor
Name:
BDBM50215994
Synonyms:
CHEMBL247743 | cis-4-((2-methylquinolin-4-yl)methoxy)-N-(1-(methylsulfonyl)-4-(5-thioxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)piperidin-3-yl)benzamide
Type:
Small organic molecule
Emp. Form.:
C26H28N6O4S2
Mol. Mass.:
552.668
SMILES:
Cc1cc(COc2ccc(cc2)C(=O)N[C@@H]2CN(CC[C@@H]2c2n[nH]c(=S)[nH]2)S(C)(=O)=O)c2ccccc2n1
Structure:
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