Reaction Details Report a problem with these data
Target
C-C chemokine receptor type 5
Ligand
BDBM50216435
Substrate
n/a
Meas. Tech.
ChEMBL_456649 (CHEMBL923004)
IC50
1000±n/a nM
Citation
 Lagu, B; Gerchak, C; Pan, M; Hou, C; Singer, M; Malaviya, R; Matheis, M; Olini, G; Cavender, D; Wachter, M Potent and selective CC-chemokine receptor-2 (CCR2) antagonists as a potential treatment for asthma. Bioorg Med Chem Lett 17:4382-6 (2007) [PubMed]  Article 
Target
Name:
C-C chemokine receptor type 5
Synonyms:
C-C CKR-5 | C-C chemokine receptor type 5 | CC-CKR-5 | CCR-5 | CCR5 | CCR5/mu opioid receptor complex | CCR5_HUMAN | CD_antigen=CD195 | CHEMR13 | CMKBR5 | HIV-1 fusion coreceptor
Type:
Enzyme
Mol. Mass.:
40540.21
Organism:
Homo sapiens (Human)
Description:
P51681
Residue:
352
Sequence:
MDYQVSSPIYDINYYTSEPCQKINVKQIAARLLPPLYSLVFIFGFVGNMLVILILINCKRLKSMTDIYLLNLAISDLFFLLTVPFWAHYAAAQWDFGNTMCQLLTGLYFIGFFSGIFFIILLTIDRYLAVVHAVFALKARTVTFGVVTSVITWVVAVFASLPGIIFTRSQKEGLHYTCSSHFPYSQYQFWKNFQTLKIVILGLVLPLLVMVICYSGILKTLLRCRNEKKRHRAVRLIFTIMIVYFLFWAPYNIVLLLNTFQEFFGLNNCSSSNRLDQAMQVTETLGMTHCCINPIIYAFVGEKFRNYLLVFFQKHIAKRFCKCCSIFQQEAPERASSVYTRSTGEQEISVGL
  
Inhibitor
Name:
BDBM50216435
Synonyms:
CHEMBL397647 | N-(4-(3,4-dichlorobenzamido)benzyl)-N,N-dimethyl-tetrahydro-2H-pyran-4-aminium
Type:
Small organic molecule
Emp. Form.:
C21H25Cl2N2O2
Mol. Mass.:
408.341
SMILES:
C[N+](C)(Cc1ccc(NC(=O)c2ccc(Cl)c(Cl)c2)cc1)C1CCOCC1
Structure:
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