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Target
Alpha-2A adrenergic receptor
Ligand
BDBM50029051
Substrate
n/a
Meas. Tech.
ChEMBL_444829 (CHEMBL895080)
EC50
372±n/a nM
Citation
 Crassous, PA; Cardinaletti, C; Carrieri, A; Bruni, B; Di Vaira, M; Gentili, F; Ghelfi, F; Giannella, M; Paris, H; Piergentili, A; Quaglia, W; Schaak, S; Vesprini, C; Pigini, M Alpha2-adrenoreceptors profile modulation. 3.1 (R)-(+)-m-nitrobiphenyline, a new efficient and alpha2C-subtype selective agonist. J Med Chem 50:3964-8 (2007) [PubMed]  Article 
Target
Name:
Alpha-2A adrenergic receptor
Synonyms:
ADA2A_HUMAN | ADRA2A | ADRA2R | ADRAR | Adrenergic alpha2A | Adrenergic receptor alpha | Alpha-2 adrenergic receptor subtype C10 | Alpha-2A adrenoceptor | Alpha-2A adrenoreceptor | Alpha-2AAR | alpha-2A adrenergic receptor [Homo sapiens]
Type:
Enzyme
Mol. Mass.:
48979.91
Organism:
Homo sapiens (Human)
Description:
P08913
Residue:
450
Sequence:
MGSLQPDAGNASWNGTEAPGGGARATPYSLQVTLTLVCLAGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIITVWVISAVISFPPLISIEKKGGGGGPQPAEPRCEINDQKWYVISSCIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDAVAAPPGGTERRPNGLGPERSAGPGGAEAEPLPTQLNGAPGEPAPAGPRDTDALDLEESSSSDHAERPPGPRRPERGPRGKGKARASQVKPGDSLPRRGPGATGIGTPAAGPGEERVGAAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAVGCSVPRTLFKFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV
  
Inhibitor
Name:
BDBM50029051
Synonyms:
(-)-arterenol | (-)-noradrenaline | (-)-norepinephrine | (R)-(-)-norepinephrine | (R)-4-(2-amino-1-hydroxyethyl)-1,2-benzenediol | (R)-noradrenaline | (R)-norepinephrine | 4-[(1R)-2-amino-1-hydroxyethyl]benzene-1,2-diol | CHEMBL1437 | NOREPINEPHRINE
Type:
Small organic molecule
Emp. Form.:
C8H11NO3
Mol. Mass.:
169.1778
SMILES:
NC[C@H](O)c1ccc(O)c(O)c1 |r|
Structure:
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