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TargetSerine/threonine-protein kinase Aurora-C
LigandBDBM50218900
Substrate/Competitorn/a
Meas. Tech.ChEMBL_445191
IC50 1000±n/a nM
Citation Myrianthopoulos, VMagiatis, PFerandin, YSkaltsounis, ALMeijer, LMikros, E An integrated computational approach to the phenomenon of potent and selective inhibition of aurora kinases B and C by a series of 7-substituted indirubins. J Med Chem50:4027-37 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Serine/threonine-protein kinase Aurora-C
Name:Serine/threonine-protein kinase Aurora-C
Synonyms:Aurora kinase C | Aurora kinase C (AURKC) | Aurora-C | Aurora/Ipl1-related kinase 3 | Aurora/Ipl1/Eg2 protein 2 | Serine/threonine-protein kinase 13
Type:Enzyme
Mol. Mass.:35602.43
Organism:Homo sapiens (Human)
Description:Amino acid residues 1-309 were expressed as His-tagged fusion protein using baculovirus expression system.
Residue:309
Sequence:
MSSPRAVVQLGKAQPAGEELATANQTAQQPSSPAMRRLTVDDFEIGRPLGKGKFGNVYLA
RLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQHPNILRLYNYFHDARRVYLIL
EYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHDKKVIHRDIKPENLLLGFRGEV
KIADFGWSVHTPSLRRKTMCGTLDYLPPEMIEGRTYDEKVDLWCIGVLCYELLVGYPPFE
SASHSETYRRILKVDVRFPLSMPLGARDLISRLLRYQPLERLPLAQILKHPWVQAHSRRV
LPPCAQMAS
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50218900
NameBDBM50218900
Synonyms:7-fluoroindirubin-3-acetoxime | CHEMBL243985
TypeSmall organic molecule
Emp. Form.C18H12FN3O3
Mol. Mass.337.3046
SMILESCC(=O)ON=C1C(Nc2ccccc12)=C1C(=O)Nc2c1cccc2F |w:6.6,4.3|
Structure
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n/a