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TargetThrombopoietin receptor
LigandBDBM50219633
Substrate/Competitorn/a
Meas. Tech.ChEMBL_457234
EC50 23±n/a nM
Citation Reiter, LASubramanyam, CMangual, EJJones, CSSmeets, MIBrissette, WHMcCurdy, SPLira, PDLinde, RGLi, QZhang, FAntipas, ASBlumberg, LCDoty, JLDriscoll, JPMunchhof, MJRipp, SLShavnya, AShepard, RMSperger, DThomasco, LMTrevena, KAWolf-Gouveia, LAZhang, L Pyrimidine benzamide-based thrombopoietin receptor agonists. Bioorg Med Chem Lett17:5447-54 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Thrombopoietin receptor
Name:Thrombopoietin receptor
Synonyms:C-mpl | CD_antigen=CD110 | Myeloproliferative leukemia protein | TPO-R
Type:PROTEIN
Mol. Mass.:71243.48
Organism:Homo sapiens
Description:ChEMBL_535587
Residue:635
Sequence:
MPSWALFMVTSCLLLAPQNLAQVSSQDVSLLASDSEPLKCFSRTFEDLTCFWDEEEAAPS
GTYQLLYAYPREKPRACPLSSQSMPHFGTRYVCQFPDQEEVRLFFPLHLWVKNVFLNQTR
TQRVLFVDSVGLPAPPSIIKAMGGSQPGELQISWEEPAPEISDFLRYELRYGPRDPKNST
GPTVIQLIATETCCPALQRPHSASALDQSPCAQPTMPWQDGPKQTSPSREASALTAEGGS
CLISGLQPGNSYWLQLRSEPDGISLGGSWGSWSLPVTVDLPGDAVALGLQCFTLDLKNVT
CQWQQQDHASSQGFFYHSRARCCPRDRYPIWENCEEEEKTNPGLQTPQFSRCHFKSRNDS
IIHILVEVTTAPGTVHSYLGSPFWIHQAVRLPTPNLHWREISSGHLELEWQHPSSWAAQE
TCYQLRYTGEGHQDWKVLEPPLGARGGTLELRPRSRYRLQLRARLNGPTYQGPWSSWSDP
TRVETATETAWISLVTALHLVLGLSAVLGLLLLRWQFPAHYRRLRHALWPSLPDLHRVLG
QYLRDTAALSPPKATVSDTCEEVEPSLLEILPKSSERTPLPLCSSQAQMDYRRLQPSCLG
TMPLSVCPPMAESGSCCTTHIANHSYLPLSYWQQP
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50219633
NameBDBM50219633
Synonyms:4-(6-(azetidin-1-yl)pyrimidin-4-ylamino)-N-(4-(2-fluoro-3-(trifluoromethyl)phenyl)thiazol-2-yl)benzamide | CHEMBL248217
TypeSmall organic molecule
Emp. Form.C24H18F4N6OS
Mol. Mass.514.498
SMILESFc1c(cccc1C(F)(F)F)-c1csc(NC(=O)c2ccc(Nc3cc(ncn3)N3CCC3)cc2)n1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a