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TargetThrombopoietin receptor
LigandBDBM50219621
Substrate/Competitorn/a
Meas. Tech.ChEMBL_457234
EC50 27±n/a nM
Citation Reiter, LASubramanyam, CMangual, EJJones, CSSmeets, MIBrissette, WHMcCurdy, SPLira, PDLinde, RGLi, QZhang, FAntipas, ASBlumberg, LCDoty, JLDriscoll, JPMunchhof, MJRipp, SLShavnya, AShepard, RMSperger, DThomasco, LMTrevena, KAWolf-Gouveia, LAZhang, L Pyrimidine benzamide-based thrombopoietin receptor agonists. Bioorg Med Chem Lett17:5447-54 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Thrombopoietin receptor
Name:Thrombopoietin receptor
Synonyms:C-mpl | CD_antigen=CD110 | Myeloproliferative leukemia protein | TPO-R
Type:PROTEIN
Mol. Mass.:71243.48
Organism:Homo sapiens
Description:ChEMBL_535587
Residue:635
Sequence:
MPSWALFMVTSCLLLAPQNLAQVSSQDVSLLASDSEPLKCFSRTFEDLTCFWDEEEAAPS
GTYQLLYAYPREKPRACPLSSQSMPHFGTRYVCQFPDQEEVRLFFPLHLWVKNVFLNQTR
TQRVLFVDSVGLPAPPSIIKAMGGSQPGELQISWEEPAPEISDFLRYELRYGPRDPKNST
GPTVIQLIATETCCPALQRPHSASALDQSPCAQPTMPWQDGPKQTSPSREASALTAEGGS
CLISGLQPGNSYWLQLRSEPDGISLGGSWGSWSLPVTVDLPGDAVALGLQCFTLDLKNVT
CQWQQQDHASSQGFFYHSRARCCPRDRYPIWENCEEEEKTNPGLQTPQFSRCHFKSRNDS
IIHILVEVTTAPGTVHSYLGSPFWIHQAVRLPTPNLHWREISSGHLELEWQHPSSWAAQE
TCYQLRYTGEGHQDWKVLEPPLGARGGTLELRPRSRYRLQLRARLNGPTYQGPWSSWSDP
TRVETATETAWISLVTALHLVLGLSAVLGLLLLRWQFPAHYRRLRHALWPSLPDLHRVLG
QYLRDTAALSPPKATVSDTCEEVEPSLLEILPKSSERTPLPLCSSQAQMDYRRLQPSCLG
TMPLSVCPPMAESGSCCTTHIANHSYLPLSYWQQP
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50219621
NameBDBM50219621
Synonyms:4-(pyrimidin-4-ylamino)-N-(7-trifluoromethyl-4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulen-2-yl)-benzamide | CHEMBL245795
TypeSmall organic molecule
Emp. Form.C23H16F3N5O2S
Mol. Mass.483.466
SMILESFC(F)(F)c1cccc2-c3nc(NC(=O)c4ccc(Nc5ccncn5)cc4)sc3CCOc12
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a