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Target
Thrombopoietin receptor
Ligand
BDBM50219698
Substrate
n/a
Meas. Tech.
ChEMBL_457234 (CHEMBL941720)
EC50
43±n/a nM
Citation
 Reiter, LA; Subramanyam, C; Mangual, EJ; Jones, CS; Smeets, MI; Brissette, WH; McCurdy, SP; Lira, PD; Linde, RG; Li, Q; Zhang, F; Antipas, AS; Blumberg, LC; Doty, JL; Driscoll, JP; Munchhof, MJ; Ripp, SL; Shavnya, A; Shepard, RM; Sperger, D; Thomasco, LM; Trevena, KA; Wolf-Gouveia, LA; Zhang, L Pyrimidine benzamide-based thrombopoietin receptor agonists. Bioorg Med Chem Lett 17:5447-54 (2007) [PubMed]  Article 
Target
Name:
Thrombopoietin receptor
Synonyms:
C-mpl | CD_antigen=CD110 | MPL | Myeloproliferative leukemia protein | TPO-R | TPOR | TPOR_HUMAN
Type:
PROTEIN
Mol. Mass.:
71243.48
Organism:
Homo sapiens (Human)
Description:
ChEMBL_535587
Residue:
635
Sequence:
MPSWALFMVTSCLLLAPQNLAQVSSQDVSLLASDSEPLKCFSRTFEDLTCFWDEEEAAPSGTYQLLYAYPREKPRACPLSSQSMPHFGTRYVCQFPDQEEVRLFFPLHLWVKNVFLNQTRTQRVLFVDSVGLPAPPSIIKAMGGSQPGELQISWEEPAPEISDFLRYELRYGPRDPKNSTGPTVIQLIATETCCPALQRPHSASALDQSPCAQPTMPWQDGPKQTSPSREASALTAEGGSCLISGLQPGNSYWLQLRSEPDGISLGGSWGSWSLPVTVDLPGDAVALGLQCFTLDLKNVTCQWQQQDHASSQGFFYHSRARCCPRDRYPIWENCEEEEKTNPGLQTPQFSRCHFKSRNDSIIHILVEVTTAPGTVHSYLGSPFWIHQAVRLPTPNLHWREISSGHLELEWQHPSSWAAQETCYQLRYTGEGHQDWKVLEPPLGARGGTLELRPRSRYRLQLRARLNGPTYQGPWSSWSDPTRVETATETAWISLVTALHLVLGLSAVLGLLLLRWQFPAHYRRLRHALWPSLPDLHRVLGQYLRDTAALSPPKATVSDTCEEVEPSLLEILPKSSERTPLPLCSSQAQMDYRRLQPSCLGTMPLSVCPPMAESGSCCTTHIANHSYLPLSYWQQP
  
Inhibitor
Name:
BDBM50219698
Synonyms:
4-(6-(dimethylamino)pyrimidin-4-ylamino)-N-(3-(4-fluoro-3-(trifluoromethyl)phenyl)-1,2,4-thiadiazol-5-yl)benzamide | CHEMBL247240
Type:
Small organic molecule
Emp. Form.:
C22H17F4N7OS
Mol. Mass.:
503.475
SMILES:
CN(C)c1cc(Nc2ccc(cc2)C(=O)Nc2nc(ns2)-c2ccc(F)c(c2)C(F)(F)F)ncn1
Structure:
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