Reaction Details Report a problem with these data
Target
Type-1 angiotensin II receptor A
Ligand
BDBM50221297
Substrate
n/a
Meas. Tech.
ChEMBL_457557 (CHEMBL922757)
Ki
>10000±n/a nM
Citation
 Murugaiah, AM; Wallinder, C; Mahalingam, AK; Wu, X; Wan, Y; Plouffe, B; Botros, M; Karlén, A; Hallberg, M; Gallo-Payet, N; Alterman, M Selective angiotensin II AT(2) receptor agonists devoid of the imidazole ring system. Bioorg Med Chem 15:7166-83 (2007) [PubMed]  Article 
Target
Name:
Type-1 angiotensin II receptor A
Synonyms:
AGTRA_RAT | ANGIOTENSIN AT1 | Agtr1 | Agtr1a | Angiotensin II AT1 | Angiotensin II AT1A | Angiotensin II receptor (AT-1) type-1 | At1a | Type-1A angiotensin II receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
40910.53
Organism:
RAT
Description:
ANGIOTENSIN AT1 AGTR1 RAT::P25095
Residue:
359
Sequence:
MALNSSAEDGIKRIQDDCPKAGRHSYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNHLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLMAGLASLPAVIHRNVYFIENTNITVCAFHYESRNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFRIIMAIVLFFFFSWVPHQIFTFLDVLIQLGVIHDCKISDIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPKAKSHSSLSTKMSTLSYRPSDNMSSSAKKPASCFEVE
  
Inhibitor
Name:
BDBM50221297
Synonyms:
CHEMBL239393 | N-butyloxycarbonyl-3-[4-(N,N-dimethylcarbamoylmethyl)phenyl]-5-iso-butylthiophene-2-sulfonamide | butyl 3-(4-(2-(dimethylamino)-2-oxoethyl)phenyl)-5-isobutylthiophen-2-ylsulfonylcarbamate
Type:
Small organic molecule
Emp. Form.:
C23H32N2O5S2
Mol. Mass.:
480.641
SMILES:
CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(CC(=O)N(C)C)cc1
Structure:
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