Reaction Details Report a problem with these data
Target
C-C chemokine receptor type 2
Ligand
BDBM50222234
Substrate
n/a
Meas. Tech.
ChEMBL_457760 (CHEMBL924037)
IC50
2300±n/a nM
Citation
 Xia, M; Hou, C; Pollack, S; Brackley, J; DeMong, D; Pan, M; Singer, M; Matheis, M; Olini, G; Cavender, D; Wachter, M Synthesis and biological evaluation of phenyl piperidine derivatives as CCR2 antagonists. Bioorg Med Chem Lett 17:5964-8 (2007) [PubMed]  Article 
Target
Name:
C-C chemokine receptor type 2
Synonyms:
C-C chemokine receptor type 2 (CCR2) | CCR2 | CCR2_HUMAN | CMKBR2 | Chemoattractant Cytokine Receptor 2 (CCR2) | Chemokine Receptor Type 2b (CCR2b) | Monocyte chemotactic protein-1 (MCP-1)
Type:
Enzyme
Mol. Mass.:
41932.32
Organism:
Homo sapiens (Human)
Description:
P41597
Residue:
374
Sequence:
MLSTSRSRFIRNTNESGEEVTTFFDYDYGAPCHKFDVKQIGAQLLPPLYSLVFIFGFVGNMLVVLILINCKKLKCLTDIYLLNLAISDLLFLITLPLWAHSAANEWVFGNAMCKLFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWLVAVFASVPGIIFTKCQKEDSVYVCGPYFPRGWNNFHTIMRNILGLVLPLLIMVICYSGILKTLLRCRNEKKRHRAVRVIFTIMIVYFLFWTPYNIVILLNTFQEFFGLSNCESTSQLDQATQVTETLGMTHCCINPIIYAFVGEKFRSLFHIALGCRIAPLQKPVCGGPGVRPGKNVKVTTQGLLDGRGKGKSIGRAPEASLQDKEGA
  
Inhibitor
Name:
BDBM50222234
Synonyms:
(E)-3-(4-fluorophenyl)-N-(4-(4-(4-methoxyphenyl)piperidin-1-yl)butyl)acrylamide | CHEMBL248638
Type:
Small organic molecule
Emp. Form.:
C25H31FN2O2
Mol. Mass.:
410.5242
SMILES:
COc1ccc(cc1)C1CCN(CCCCNC(=O)\C=C\c2ccc(F)cc2)CC1
Structure:
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