Reaction Details Report a problem with these data
Target
Equilibrative nucleoside transporter 1
Ligand
BDBM50222755
Substrate
n/a
Meas. Tech.
ChEMBL_458014 (CHEMBL924283)
Ki
11±n/a nM
Citation
 Gupte, A; Buolamwini, JK Novel C2-purine position analogs of nitrobenzylmercaptopurine riboside as human equilibrative nucleoside transporter 1 inhibitors. Bioorg Med Chem 15:7726-37 (2007) [PubMed]  Article 
Target
Name:
Equilibrative nucleoside transporter 1
Synonyms:
ENT1 | Equilibrative NBMPR-sensitive nucleoside transporter | Equilibrative Nucleoside Transporter 1 (ENT1) | Equilibrative nitrobenzylmercaptopurine riboside-sensitive nucleoside transporter | Equilibrative nucleoside transporter 1 | Nucleoside transporter, es-type | S29A1_HUMAN | SLC29A1 | Solute carrier family 29 member 1
Type:
Multi-pass membrane protein
Mol. Mass.:
50225.92
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
456
Sequence:
MTTSHQPQDRYKAVWLIFFMLGLGTLLPWNFFMTATQYFTNRLDMSQNVSLVTAELSKDAQASAAPAAPLPERNSLSAIFNNVMTLCAMLPLLLFTYLNSFLHQRIPQSVRILGSLVAILLVFLITAILVKVQLDALPFFVITMIKIVLINSFGAILQGSLFGLAGLLPASYTAPIMSGQGLAGFFASVAMICAIASGSELSESAFGYFITACAVIILTIICYLGLPRLEFYRYYQQLKLEGPGEQETKLDLISKGEEPRAGKEESGVSVSNSQPTNESHSIKAILKNISVLAFSVCFIFTITIGMFPAVTVEVKSSIAGSSTWERYFIPVSCFLTFNIFDWLGRSLTAVFMWPGKDSRWLPSLVLARLVFVPLLLLCNIKPRRYLTVVFEHDAWFIFFMAAFAFSNGYLASLCMCFGPKKVKPAEAETAGAIMAFFLCLGLALGAVFSFLFRAIV
  
Inhibitor
Name:
BDBM50222755
Synonyms:
2-bromo-6-(4-nitrobenzylthio)-9-beta-D-ribofuranosylpurine | CHEMBL239889
Type:
Small organic molecule
Emp. Form.:
C17H16BrN5O6S
Mol. Mass.:
498.308
SMILES:
OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(SCc3ccc(cc3)[N+]([O-])=O)nc(Br)nc12
Structure:
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