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Target
Muscarinic acetylcholine receptor M1
Ligand
BDBM50223995
Substrate
n/a
Meas. Tech.
ChEMBL_450371 (CHEMBL900656)
IC50
15.8±n/a nM
Citation
 Lainé, DI; Xie, H; Buffet, N; Foley, JJ; Buckley, P; Webb, EF; Widdowson, KL; Palovich, MR; Belmonte, KE Discovery of novel 8-azoniabicyclo[3.2.1]octane carbamates as muscarinic acetylcholine receptor antagonists. Bioorg Med Chem Lett 17:6066-9 (2007) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M1
Synonyms:
ACM1_HUMAN | CHRM1 | Cholinergic receptor, muscarinic 1 | Cholinergic, muscarinic M1
Type:
Protein
Mol. Mass.:
51442.54
Organism:
Homo sapiens (Human)
Description:
P11229
Residue:
460
Sequence:
MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
  
Inhibitor
Name:
BDBM50223995
Synonyms:
8,8-dimethyl-3-[(5-methyl-thiophen-2-ylmethyl)-phenyl-carbamoyloxy]-8-azonia-bicyclo[3.2.1]octane; bromide | CHEMBL237527
Type:
Small organic molecule
Emp. Form.:
C22H29N2O2S
Mol. Mass.:
385.542
SMILES:
Cc1ccc(CN(C(=O)OC2CC3CCC(C2)[N+]3(C)C)c2ccccc2)s1 |w:15.15,12.12,TLB:9:10:17:13.14|
Structure:
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