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Target
Serine/threonine-protein kinase Chk1
Ligand
BDBM15249
Substrate
n/a
Meas. Tech.
ChEMBL_450842 (CHEMBL899928)
IC50
6±n/a nM
Citation
 Li, G; Tao, ZF; Tong, Y; Przytulinska, MK; Kovar, P; Merta, P; Chen, Z; Zhang, H; Sowin, T; Rosenberg, SH; Lin, NH Synthesis and in-vitro biological activity of macrocyclic urea Chk1 inhibitors. Bioorg Med Chem Lett 17:6499-504 (2007) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase Chk1
Synonyms:
CHEK1 | CHK1 | CHK1 checkpoint homolog | CHK1_HUMAN | Checkpoint kinase-1 (CHK1)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
54443.02
Organism:
Homo sapiens (Human)
Description:
gi_166295192
Residue:
476
Sequence:
MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINKMLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDFSPVNSASSEENVKYSSSQPEPRTGLSLWDTSPSYIDKLVQGISFSQPTCPDHMLLNSQLLGTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKSCMNQVTISTTDRRNNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLIDIVSSQKIWLPAT
  
Inhibitor
Name:
BDBM15249
Synonyms:
7-chloro-3-oxo-11,16-dioxa-2,4,19,21-tetraazatricyclo[15.3.1.0^{5,10}]henicosa-1(20),5(10),6,8,17(21),18-hexaene-18-carbonitrile | CHEMBL375097 | macrocyclic inhibitor 5c
Type:
Small organic molecule
Emp. Form.:
C16H14ClN5O3
Mol. Mass.:
359.767
SMILES:
Clc1ccc2OCCCCOc3nc(NC(=O)Nc2c1)cnc3C#N
Structure:
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