Reaction Details Report a problem with these data
Target
Aurora kinase C
Ligand
BDBM50224734
Substrate
n/a
Meas. Tech.
ChEMBL_450879 (CHEMBL899965)
IC50
227±n/a nM
Citation
 Bavetsias, V; Sun, C; Bouloc, N; Reynisson, J; Workman, P; Linardopoulos, S; McDonald, E Hit generation and exploration: imidazo[4,5-b]pyridine derivatives as inhibitors of Aurora kinases. Bioorg Med Chem Lett 17:6567-71 (2007) [PubMed]  Article 
Target
Name:
Aurora kinase C
Synonyms:
AIE2 | AIK3 | AIRK3 | ARK3 | AURKC | AURKC_HUMAN | Aurora Kinase C (Aurora-C) | Aurora kinase C | Aurora kinase C (AURKC) | Aurora-C | Aurora-C/INCENP | Aurora/Ipl1-related kinase 3 | Aurora/Ipl1/Eg2 protein 2 | STK13 | Serine/threonine-protein kinase 13 | Serine/threonine-protein kinase Aurora-C
Type:
Enzyme
Mol. Mass.:
35602.43
Organism:
Homo sapiens (Human)
Description:
Amino acid residues 1-309 were expressed as His-tagged fusion protein using baculovirus expression system.
Residue:
309
Sequence:
MSSPRAVVQLGKAQPAGEELATANQTAQQPSSPAMRRLTVDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQHPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHDKKVIHRDIKPENLLLGFRGEVKIADFGWSVHTPSLRRKTMCGTLDYLPPEMIEGRTYDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGARDLISRLLRYQPLERLPLAQILKHPWVQAHSRRVLPPCAQMAS
  
Inhibitor
Name:
BDBM50224734
Synonyms:
2-(4-(6-Chloro-2-(4-(dimethylamino)phenyl)-3H-imidazo[4,5-b]-pyridin-7-yl)piperazin-1-yl)-N-(thiazol-2-yl)acetamide | 2-(4-(6-chloro-2-(4-(dimethylamino)phenyl)-3H-imidazo[4,5-b]pyridin-7-yl)piperazin-1-yl)-N-(thiazol-2-yl)acetamide | CHEMBL392525
Type:
Small organic molecule
Emp. Form.:
C23H25ClN8OS
Mol. Mass.:
497.016
SMILES:
CN(C)c1ccc(cc1)-c1nc2ncc(Cl)c(N3CCN(CC(=O)Nc4nccs4)CC3)c2[nH]1
Structure:
Search PDB for entries with ligand similarity: