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TargetDipeptidyl peptidase 4
LigandBDBM50225054
Substrate/Competitorn/a
Meas. Tech.ChEMBL_450927
Ki>10000±n/a nM
Citation Simpkins, LMBolton, SPi, ZSutton, JCKwon, CZhao, GMagnin, DRAugeri, DJGungor, TRotella, DPSun, ZLiu, YSlusarchyk, WSMarcinkeviciene, JRobertson, JGWang, ARobl, JAAtwal, KSZahler, RLParker, RAKirby, MSHamann, LG Potent non-nitrile dipeptidic dipeptidyl peptidase IV inhibitors. Bioorg Med Chem Lett17:6476-80 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Dipeptidyl peptidase 4
Name:Dipeptidyl peptidase II and dipeptidyl peptidase IV (DPP2 and DPP4)
Synonyms:ADABP | ADCP2 | Adenosine deaminase complexing protein 2 | CD26 | CD_antigen=CD26 | DPP IV | DPP4 | DPPIV | Dipeptidyl peptidase 4 (DDP-IV) | Dipeptidyl peptidase 4 (DPP IV) | Dipeptidyl peptidase 4 (DPP-4) | Dipeptidyl peptidase 4 (DPP4) | Dipeptidyl peptidase 4 (DPPIV) | Dipeptidyl peptidase 4 membrane form | Dipeptidyl peptidase 4 soluble form | Dipeptidyl peptidase IV | Dipeptidyl peptidase IV (DDP-4) | Dipeptidyl peptidase IV (DDP-IV) | Dipeptidyl peptidase IV (DPP IV) | Dipeptidyl peptidase IV membrane form | Dipeptidyl peptidase IV soluble form | Dipeptidyl peptidase-IV (DPP-4) | Dipeptidyl peptidase-IV (DPP-IV) | T-cell activation antigen CD26 | TP103
Type:Enzyme
Mol. Mass.:88271.01
Organism:Homo sapiens (Human)
Description:P27487
Residue:766
Sequence:
MKTPWKVLLGLLGAAALVTIITVPVVLLNKGTDDATADSRKTYTLTDYLKNTYRLKLYSL
RWISDHEYLYKQENNILVFNAEYGNSSVFLENSTFDEFGHSINDYSISPDGQFILLEYNY
VKQWRHSYTASYDIYDLNKRQLITEERIPNNTQWVTWSPVGHKLAYVWNNDIYVKIEPNL
PSYRITWTGKEDIIYNGITDWVYEEEVFSAYSALWWSPNGTFLAYAQFNDTEVPLIEYSF
YSDESLQYPKTVRVPYPKAGAVNPTVKFFVVNTDSLSSVTNATSIQITAPASMLIGDHYL
CDVTWATQERISLQWLRRIQNYSVMDICDYDESSGRWNCLVARQHIEMSTTGWVGRFRPS
EPHFTLDGNSFYKIISNEEGYRHICYFQIDKKDCTFITKGTWEVIGIEALTSDYLYYISN
EYKGMPGGRNLYKIQLSDYTKVTCLSCELNPERCQYYSVSFSKEAKYYQLRCSGPGLPLY
TLHSSVNDKGLRVLEDNSALDKMLQNVQMPSKKLDFIILNETKFWYQMILPPHFDKSKKY
PLLLDVYAGPCSQKADTVFRLNWATYLASTENIIVASFDGRGSGYQGDKIMHAINRRLGT
FEVEDQIEAARQFSKMGFVDNKRIAIWGWSYGGYVTSMVLGSGSGVFKCGIAVAPVSRWE
YYDSVYTERYMGLPTPEDNLDHYRNSTVMSRAENFKQVEYLLIHGTADDNVHFQQSAQIS
KALVDVGVDFQAMWYTDEDHGIASSTAHQHIYTHMSHFIKQCFSLP
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50225054
NameBDBM50225054
Synonyms:(S)-2-amino-1-(2,3-dihydro-indol-1-yl)-2-(3-hydroxy-adamantan-1-yl)-ethanone | CHEMBL400230
TypeSmall organic molecule
Emp. Form.C20H26N2O2
Mol. Mass.326.4326
SMILESN[C@H](C(=O)N1CCc2ccccc12)C12CC3CC(CC(O)(C3)C1)C2 |w:13.25,15.23,19.21,17.26,TLB:16:17:22:21.14.15,THB:14:13:18:21.15.16,14:15:22.13.23:18,16:15:22:23.17.18,1:13:18:21.15.16,TEB:23:17:21:22.13.14|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
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