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Reaction Details
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TargetTransthyretin
LigandBDBM50225220
Substrate/Competitorn/a
Meas. Tech.ChEMBL_451108
pH4.4±n/a
IC50 7170±n/a nM
Commentsextracted
Citation Gupta, SChhibber, MSinha, SSurolia, A Design of mechanism-based inhibitors of transthyretin amyloidosis: studies with biphenyl ethers and new structural templates. J Med Chem50:5589-99 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Transthyretin
Name:Transthyretin
Synonyms:ATTR | PALB | Prealbumin | TBPA | TTR | Transthyretin (TTR)
Type:Enzyme
Mol. Mass.:15884.31
Organism:Homo sapiens (Human)
Description:P02766
Residue:147
Sequence:
MASHRLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDT
WEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDS
GPRRYTIAALLSPYSYSTTAVVTNPKE
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  Blast E-value cutoff:
BDBM50225220
n/a
NameBDBM50225220
Synonyms:CHEMBL559 | D-thyroxine | O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-D-tyrosine | dextrothyroxine
TypeSmall organic molecule
Emp. Form.C15H11I4NO4
Mol. Mass.776.87
SMILESN[C@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(O)=O
Structure
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