Reaction Details Report a problem with these data
Target
C-X-C chemokine receptor type 4
Ligand
BDBM50225415
Substrate
n/a
Meas. Tech.
ChEMBL_451383 (CHEMBL901586)
EC50
0.3±n/a nM
Citation
 Zhan, W; Liang, Z; Zhu, A; Kurtkaya, S; Shim, H; Snyder, JP; Liotta, DC Discovery of small molecule CXCR4 antagonists. J Med Chem 50:5655-64 (2007) [PubMed]  Article 
Target
Name:
C-X-C chemokine receptor type 4
Synonyms:
C-X-C chemokine receptor type 4 | C-X-C chemokine receptor type 4 (CXCR4) | CD_antigen=CD184 | CXC-R4 | CXCR-4 | CXCR4 | CXCR4_HUMAN | FB22 | Fusin | HM89 | LCR1 | LESTR | Leukocyte-derived seven transmembrane domain receptor | NPYRL | SDF-1 receptor | Stromal cell-derived factor 1 receptor
Type:
Enzyme
Mol. Mass.:
39754.61
Organism:
Homo sapiens (Human)
Description:
P61073
Residue:
352
Sequence:
MEGISIYTSDNYTEEMGSGDYDSMKEPCFREENANFNKIFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAVANWYFGNFLCKAVHVIYTVNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADDRYICDRFYPNDLWVVVFQFQHIMVGLILPGIVILSCYCIIISKLSHSKGHQKRKALKTTVILILAFFACWLPYYIGISIDSFILLEIIKQGCEFENTVHKWISITEALAFFHCCLNPILYAFLGAKFKTSAQHALTSVSRGSSLKILSKGKRGGHSSVSTESESSSFHSS
  
Inhibitor
Name:
BDBM50225415
Synonyms:
CHEMBL237830 | N,N'-di-2-pyridinyl-1,4-benzenedimethanamine | US9205085, MSX- 121 | WZ-811
Type:
Small organic molecule
Emp. Form.:
C18H18N4
Mol. Mass.:
290.3623
SMILES:
C(Nc1ccccn1)c1ccc(CNc2ccccn2)cc1
Structure:
Search PDB for entries with ligand similarity: