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Target
4-hydroxy-2-oxoglutarate aldolase, mitochondrial
Ligand
BDBM50160721
Substrate
n/a
Meas. Tech.
ChEMBL_461876 (CHEMBL929012)
Ki
170000±n/a nM
Citation
 Boughton, BA; Dobson, RC; Gerrard, JA; Hutton, CA Conformationally constrained diketopimelic acid analogues as inhibitors of dihydrodipicolinate synthase. Bioorg Med Chem Lett 18:460-3 (2008) [PubMed]  Article 
Target
Name:
4-hydroxy-2-oxoglutarate aldolase, mitochondrial
Synonyms:
2-keto-4-hydroxyglutarate aldolase | 4-hydroxy-2-oxoglutarate aldolase, mitochondrial | C10orf65 | DHDPS-like protein | DHDPSL | Dihydrodipicolinate synthase-like, mitochondrial | HOGA1 | HOGA1_HUMAN | Probable KHG-aldolase | Protein 569272
Type:
PROTEIN
Mol. Mass.:
35253.21
Organism:
Homo sapiens (Human)
Description:
ChEMBL_461876
Residue:
327
Sequence:
MLGPQVWSSVRQGLSRSLSRNVGVWASGEGKKVDIAGIYPPVTTPFTATAEVDYGKLEENLHKLGTFPFRGFVVQGSNGEFPFLTSSERLEVVSRVRQAMPKNRLLLAGSGCESTQATVEMTVSMAQVGADAAMVVTPCYYRGRMSSAALIHHYTKVADLSPIPVVLYSVPANTGLDLPVDAVVTLSQHPNIVGMKDSGGDVTRIGLIVHKTRKQDFQVLAGSAGFLMASYALGAVGGVCALANVLGAQVCQLERLCCTGQWEDAQKLQHRLIEPNAAVTRRFGIPGLKKIMDWFGYYGGPCRAPLQELSPAEEEALRMDFTSNGWL
  
Inhibitor
Name:
BDBM50160721
Synonyms:
2-Oxo-heptanedioic acid | 2-oxoheptanedioic acid | CHEMBL185075 | alpha-ketopimelic acid
Type:
Small organic molecule
Emp. Form.:
C7H10O5
Mol. Mass.:
174.1513
SMILES:
OC(=O)CCCCC(=O)C(O)=O
Structure:
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