Reaction Details Report a problem with these data
Target
Autoinducer 2-binding periplasmic protein LuxP
Ligand
BDBM4341
Substrate
n/a
Meas. Tech.
ChEMBL_462614 (CHEMBL929603)
IC50
3000±n/a nM
Citation
 Ni, N; Choudhary, G; Li, M; Wang, B Pyrogallol and its analogs can antagonize bacterial quorum sensing in Vibrio harveyi. Bioorg Med Chem Lett 18:1567-72 (2008) [PubMed]  Article 
Target
Name:
Autoinducer 2-binding periplasmic protein LuxP
Synonyms:
LUXP_VIBHA | luxP
Type:
PROTEIN
Mol. Mass.:
41453.75
Organism:
Vibrio harveyi
Description:
ChEMBL_1513759
Residue:
365
Sequence:
MKKALLFSLISMVGFSPASQATQVLNGYWGYQEFLDEFPEQRNLTNALSEAVRAQPVPLSKPTQRPIKISVVYPGQQVSDYWVRNIASFEKRLYKLNINYQLNQVFTRPNADIKQQSLSLMEALKSKSDYLIFTLDTTRHRKFVEHVLDSTNTKLILQNITTPVREWDKHQPFLYVGFDHAEGSRELATEFGKFFPKHTYYSVLYFSEGYISDVRGDTFIHQVNRDNNFELQSAYYTKATKQSGYDAAKASLAKHPDVDFIYACSTDVALGAVDALAELGREDIMINGWGGGSAELDAIQKGDLDITVMRMNDDTGIAMAEAIKWDLEDKPVPTVYSGDFEIVTKADSPERIEALKKRAFRYSDN
  
Inhibitor
Name:
BDBM4341
Synonyms:
2-[(3,4,5-trihydroxyphenyl)methylidene]propanedinitrile | benzylidenemalononitrile (BMN) deriv. 25
Type:
Small organic molecule
Emp. Form.:
C10H6N2O3
Mol. Mass.:
202.1662
SMILES:
[#8]-c1cc(\[#6]=[#6](/C#N)C#N)cc(-[#8])c1-[#8]
Structure:
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